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Journal articleHamill JM, Ismael A, Al-Jobory A, et al., 2023,
Quantum Interference and Contact Effects in the Thermoelectric Performance of Anthracene-Based Molecules.
, J Phys Chem C Nanomater Interfaces, Vol: 127, Pages: 7484-7491, ISSN: 1932-7447We report on the single-molecule electronic and thermoelectric properties of strategically chosen anthracene-based molecules with anchor groups capable of binding to noble metal substrates, such as gold and platinum. Specifically, we study the effect of different anchor groups, as well as quantum interference, on the electric conductance and the thermopower of gold/single-molecule/gold junctions and generally find good agreement between theory and experiments. All molecular junctions display transport characteristics consistent with coherent transport and a Fermi alignment approximately in the middle of the highest occupied molecular orbital/lowest unoccupied molecular orbital gap. Single-molecule results are in agreement with previously reported thin-film data, further supporting the notion that molecular design considerations may be translated from the single- to many-molecule devices. For combinations of anchor groups where one binds significantly more strongly to the electrodes than the other, the stronger anchor group appears to dominate the thermoelectric behavior of the molecular junction. For other combinations, the choice of electrode material can determine the sign and magnitude of the thermopower. This finding has important implications for the design of thermoelectric generator devices, where both n- and p-type conductors are required for thermoelectric current generation.
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Journal articleLong NJ, Bhargava S, 2022,
Professor Edward Abel, FRSC, CBE (1931-2021)
, DALTON TRANSACTIONS, Vol: 51, Pages: 16781-16783, ISSN: 1477-9226 -
Journal articleCooper SM, Siakalli C, White AJP, et al., 2022,
Synthesis and anti-microbial activity of a new series of bis(diphosphine) rhenium(v) dioxo complexes
, DALTON TRANSACTIONS, Vol: 51, Pages: 12791-12795, ISSN: 1477-9226- Author Web Link
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- Citations: 3
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Journal articleWilkinson LA, Bennett TLR, Grace IM, et al., 2022,
Assembly, structure and thermoelectric properties of 1,1 '-dialkynylferrocene 'hinges'
, CHEMICAL SCIENCE, ISSN: 2041-6520 -
Journal articleFrei A, Rigby A, Yue TTC, et al., 2022,
To chelate thallium(i) - synthesis and evaluation of Kryptofix-based chelators for Tl-201
, DALTON TRANSACTIONS, Vol: 51, Pages: 9039-9048, ISSN: 1477-9226 -
Journal articleCooper SM, White AJP, Eykyn TR, et al., 2022,
N-Centered Tripodal Phosphine Re(V) and Tc(V) Oxo Complexes: Revisiting a [3+2] Mixed-Ligand Approach
, INORGANIC CHEMISTRY, Vol: 61, Pages: 8000-8014, ISSN: 0020-1669- Author Web Link
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- Citations: 2
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Journal articleLi Z, Li B, Wu X, et al., 2022,
Organometallic-functionalized interfaces for highly efficient inverted perovskite solar cells
, SCIENCE, Vol: 376, Pages: 416-+, ISSN: 0036-8075- Author Web Link
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- Citations: 152
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Journal articleBennett TLR, Alshammari M, Au-Yong S, et al., 2022,
Multi-component self-assembled molecular-electronic films: towards new high-performance thermoelectric systems
, CHEMICAL SCIENCE, Vol: 13, Pages: 5176-5185, ISSN: 2041-6520- Author Web Link
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- Citations: 3
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Journal articleSheppard SA, Bennett TLR, Long NJ, 2022,
Development and Characterisation of Highly Conjugated Functionalised Ferrocenylene Macrocycles
, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Vol: 2022, ISSN: 1434-1948- Author Web Link
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- Citations: 2
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Journal articleBourke S, Urbano L, Midson MM, et al., 2022,
Nearly monodispersed, emission-tuneable conjugated polymer nanoparticles
, Sensors & Diagnostics, Vol: 1, Pages: 1185-1188<jats:p>We describe the synthesis of monodispersed, silica encapsulated conjugated polymer nanoparticles, their colour tunability and use in imaging HeLa cells.</jats:p>
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Journal articleBraga M, Leow CH, Gil JH, et al., 2021,
Investigating CXCR4 expression of tumor cells and the vascular compartment: A multimodal approach
, PLoS One, Vol: 16, Pages: 1-21, ISSN: 1932-6203The C-X-C chemokine receptor 4 (CXCR4) is G protein-coupled receptor that upon binding to its cognate ligand, can lead to tumor progression. Several CXCR4-targeted therapies are currently under investigation, and with it comes the need for imaging agents capable of accurate depiction of CXCR4 for therapeutic stratification and monitoring. PET agents enjoy the most success, but more cost-effective and radiation-free approaches such as ultrasound (US) imaging could represent an attractive alternative. In this work, we developed a targeted microbubble (MB) for imaging of vascular CXCR4 expression in cancer. A CXCR4-targeted MB was developed through incorporation of the T140 peptide into the MB shell. Binding properties of the T140-MB and control, non-targeted MB (NT-MB) were evaluated in MDA-MB-231 cells where CXCR4 expression was knocked-down (via shRNA) through optical imaging, and in the lymphoma tumor models U2932 and SuDHL8 (high and low CXCR4 expression, respectively) by US imaging. PET imaging of [18F]MCFB, a tumor-penetrating CXCR4-targeted small molecule, was used to provide whole-tumor CXCR4 readouts. CXCR4 expression and microvessel density were performed by immunohistochemistry analysis and western blot. T140-MB were formed with similar properties to NT-MB and accumulated sensitively and specifically in cells according to their CXCR4 expression. In NOD SCID mice, T140-MB persisted longer in tumors than NT-MB, indicative of target interaction, but showed no difference between U2932 and SuDHL8. In contrast, PET imaging with [18F]MCFB showed a marked difference in tumor uptake at 40–60 min post-injection between the two tumor models (p<0.05). Ex vivo analysis revealed that the large differences in CXCR4 expression between the two models are not reflected in the vascular compartment, where the MB are restricted; in fact, microvessel density and CXCR4 expression in the vasculature was comparable between U2932 and SuDHL8 tumors. In conclusion, we success
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Journal articleBaker CA, Romain C, Long NJ, 2021,
Cation-pi interactions enabling hard/soft Ti/Ag heterobimetallic cooperativity in lactide ring-opening polymerisation
, CHEMICAL COMMUNICATIONS, Vol: 57, Pages: 12524-12527, ISSN: 1359-7345- Author Web Link
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- Citations: 4
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Journal articleTeh JH, Braga M, Allott L, et al., 2021,
A kit-based aluminium-[F-18]fluoride approach to radiolabelled microbubbles
, Chemical Communications, Vol: 57, Pages: 11677-11680, ISSN: 1359-7345The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels–Alder (IEDDA) ‘click’ chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans-cyclooctene (TCO) functionalised phospholipid (40–50% RCY), which was incorporated into MBs (40–50% RCY). To demonstrate the potential of producing 18F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting.
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Journal articleWalter ERH, Cooper SM, Boyle JJ, et al., 2021,
Enzyme-activated probes in optical imaging: a focus on atherosclerosis
, DALTON TRANSACTIONS, Vol: 50, Pages: 14486-14497, ISSN: 1477-9226 -
Journal articleOsborne BE, Yue TTC, Waters ECT, et al., 2021,
Synthesis and ex vivo biological evaluation of gallium-68 labelled NODAGA chelates assessing cardiac uptake and retention
, DALTON TRANSACTIONS, Vol: 50, Pages: 14695-14705, ISSN: 1477-9226
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