BibTex format
@article{Lam:2026:10.1002/ange.6507556,
author = {Lam, P and Yeung, Y and Kai, H and Xie, Y and Liu, Z and Elliott, SJ and Walter, ERH and Liu, F and Zhou, W and Wu, Y and Jiao, J and Chau, H and Law, G and Long, NJ and Bünzli, JG and Wong, K},
doi = {10.1002/ange.6507556},
journal = {Angewandte Chemie},
title = {Facile Synthesis of a Bis <i>α</i> arylSubstituted PyclenBased Heptadentate Lanthanide Chelator for UltraRobust and HighContrast MRI Agents and for Radiopharmaceuticals},
url = {http://dx.doi.org/10.1002/ange.6507556},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - <jats:title>ABSTRACT</jats:title> <jats:p> Owing to safety concerns associated with previous gadoliniumbased magnetic resonance imaging (MRI) agents, pyclenbased Gd chelates are emerging as promising alternatives. However, the development of pyclenbased chelators has been hindered by synthetic challenges. In this work, we report two new pyclenbased chelators featuring <jats:italic>α</jats:italic> arylsubstituents on two of the acetate arms. Using the Petasis reaction, two lanthanide chelators <jats:bold>3a</jats:bold> and <jats:bold>3b</jats:bold> were synthesized in just two steps from pyclen. <jats:bold>3aGd</jats:bold> exhibits superior coordination stability and relaxivity compared to previously reported Gd <jats:sup>3+</jats:sup> chelates of comparable molecular weight. It also has low cytotoxicity and produces a strong, longlasting in vivo MRI signal, enabling realtime monitoring of tissues/organs, as demonstrated in heart, liver, and kidney imaging of mice. Additionally, the chelator also shows improved coordination kinetics for In <jats:sup>3+</jats:sup> , Tb <jats:sup>3+</jats:sup> , Lu <jats:sup>3+</jats:sup> , and Y <jats:sup>3+</jats:sup> , highlighting its potential for the development of a new class of nextgeneration radiopharmaceuticals. </jats:p>
AU - Lam,P
AU - Yeung,Y
AU - Kai,H
AU - Xie,Y
AU - Liu,Z
AU - Elliott,SJ
AU - Walter,ERH
AU - Liu,F
AU - Zhou,W
AU - Wu,Y
AU - Jiao,J
AU - Chau,H
AU - Law,G
AU - Long,NJ
AU - Bünzli,JG
AU - Wong,K
DO - 10.1002/ange.6507556
PY - 2026///
SN - 0044-8249
TI - Facile Synthesis of a Bis <i>α</i> arylSubstituted PyclenBased Heptadentate Lanthanide Chelator for UltraRobust and HighContrast MRI Agents and for Radiopharmaceuticals
T2 - Angewandte Chemie
UR - http://dx.doi.org/10.1002/ange.6507556
UR - https://doi.org/10.1002/ange.6507556
ER -
