BibTex format
@article{Stasiuk:2015:10.1002/chem.201406008,
author = {Stasiuk, GJ and Minuzzi, F and Sae-Heng, M and Rivas, C and Juretschke, H-P and Piemonti, L and Allegrini, PR and Laurent, D and Duckworth, AR and Beeby, A and Rutter, GA and Long, NJ},
doi = {10.1002/chem.201406008},
journal = {Chemistry-A European Journal},
pages = {5023--5033},
title = {Dual-Modal Magnetic Resonance/Fluorescent Zinc Probes for Pancreatic beta-Cell Mass Imaging},
url = {http://dx.doi.org/10.1002/chem.201406008},
volume = {21},
year = {2015}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - : Despite the contribution of changes in pancreaticb-cell mass to the development of all forms of diabetes mellitus,few robust approaches currently exist to monitor thesechanges prospectively in vivo. Although magnetic-resonanceimaging (MRI) provides a potentially useful technique, targetingMRI-active probes to the b cell has proved challenging.Zinc ions are highly concentrated in the secretory granule,but they are relatively less abundant in the exocrinepancreas and in other tissues. We have therefore developedfunctional dual-modal probes based on transition-metal chelatescapable of binding zinc. The first of these, Gd·1, bindsZnII directly by means of an amidoquinoline moiety (AQA),thus causing a large ratiometric Stokes shift in the fluorescencefrom lem =410 to 500 nm with an increase in relaxivityfrom r1=4.2 up to 4.9 mm1 s1. The probe is efficiently accumulatedinto secretory granules in b-cell-derived lines andisolated islets, but more poorly by non-endocrine cells, andleads to a reduction in T1 in human islets. In vivo murinestudies of Gd·1 have shown accumulation of the probe inthe pancreas with increased signal intensity over 140 minutes.
AU - Stasiuk,GJ
AU - Minuzzi,F
AU - Sae-Heng,M
AU - Rivas,C
AU - Juretschke,H-P
AU - Piemonti,L
AU - Allegrini,PR
AU - Laurent,D
AU - Duckworth,AR
AU - Beeby,A
AU - Rutter,GA
AU - Long,NJ
DO - 10.1002/chem.201406008
EP - 5033
PY - 2015///
SN - 1521-3765
SP - 5023
TI - Dual-Modal Magnetic Resonance/Fluorescent Zinc Probes for Pancreatic beta-Cell Mass Imaging
T2 - Chemistry-A European Journal
UR - http://dx.doi.org/10.1002/chem.201406008
VL - 21
ER -
