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  • Journal article
    Malietzis G, Lee GH, Bernardo D, Johns N, Fearon KCH, Blakemore A, Jenkins JT, Al-Hassi H, Knight Set al., 2014,

    Muscle mass of the host and dendritic cell phenotype in patients with colorectal cancer

    , EUROPEAN JOURNAL OF CANCER, Vol: 50, Pages: S218-S218, ISSN: 0959-8049
  • Journal article
    Lee G, Malietzis G, Bernardo D, Clark SK, Knight SC, Al-Hassi HOet al., 2014,

    Circulating dendritic cells are gut homing in colorectal cancers - A role in diagnosis and prognosis in colorectal cancer?

    , EUROPEAN JOURNAL OF CANCER, Vol: 50, Pages: S217-S217, ISSN: 0959-8049
  • Journal article
    Yassin NA, Askari A, Siaw YH, Mann E, Bernardo D, Phillips RKS, Knight S, Al-Hassi H, Hart ALet al., 2014,

    Gut homing markers in perianal Crohn's fistulae

    , JOURNAL OF CROHNS & COLITIS, Vol: 8, Pages: S9-S9, ISSN: 1873-9946
  • Journal article
    Lee GH, Askari A, Malietzis G, Bernardo D, Clark SK, Knight SC, Al-Hassi HOet al., 2014,

    The Role of CD40 Expression in Dendritic Cells in Cancer Biology; A Systematic Review

    , CURRENT CANCER DRUG TARGETS, Vol: 14, Pages: 610-620, ISSN: 1568-0096
    • Cite
    • Citations: 20
  • Journal article
    Rahbour G, Al-Hassi HO, Hart AL, Ullah MR, Gabe SM, Knight SC, Warusavitarne J, Vaizey CJet al., 2013,

    Prospective study to assess tumour necrosis factor alpha in non-inflammatory bowel disease enterocutaneous fistula.

    , Int J Surg, Vol: 11, Pages: 589-590
  • Conference paper
    Al-Hassi HO, Lee G, Malietzis G, Yassin N, Mann E, Bernardo D, Phillips RK, Clark SK, Knight SCet al., 2013,

    Activation and maturation status of dendritic cells is altered in post-operative colorectal cancer patients

    , European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO, Publisher: ELSEVIER SCI LTD, Pages: S500-S500, ISSN: 0959-8049
  • Conference paper
    Lee G, Malietzis G, Yssin N, Mann E, Bernardo D, Phillips RK, Clark SK, Knight SC, Al-Hassi HOet al., 2013,

    Increased activation and migration potential of dendritic cell in patients with colorectal cancer - the implication and future of cancer immunotherapy

    , European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO, Publisher: ELSEVIER SCI LTD, Pages: S498-S499, ISSN: 0959-8049
  • Conference paper
    Yassin NA, Al-Hassi HO, Lee GH, Malietzis G, Bernardo-Ordiz D, Mann D, Phillips RK, Knight S, Hart Aet al., 2013,

    Increased Gut Homing (B7) on Dendritic cells in Fistulating Perianal Crohn’s Disease

    , ICMI
  • Journal article
    Al-Hassi HO, Bernardo D, Murugananthan AU, Mann ER, English NR, Jones A, Kamm MA, Arebi N, Hart AL, Blakemore AI, Stagg AJ, Knight SCet al., 2013,

    A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease

    , Mucosal Immunology, Vol: 6, Pages: 751-761, ISSN: 1933-0219

    Dendritic cells (DC) migrate to lymph nodes on expression of C-C motif chemokine receptor 7 (CCR7) and control immune activity. Leptin, an immunomodulatory adipokine, functions via leptin receptors, signaling via the long isoform of receptor, LepRb. Leptin promotes DC maturation and increases CCR7 expression on blood DC. Increased mesenteric fat and leptin occur early in Crohn's disease (CD), suggesting leptin-mediated change in intestinal CCR7 expression on DC as a pro-inflammatory mechanism. We have demonstrated CCR7 expression and capacity to migrate to its ligand macrophage inflammatory protein 3beta in normal human ileal DC but not colonic or blood DC. In CD, functional CCR7 was expressed on DC from all sites. Only DC populations containing CCR7-expressing cells produced LepRb; in vitro exposure to leptin also increased expression of functional CCR7 in intestinal DC in a dose-dependent manner. In conclusion, leptin may regulate DC migration from gut, in homeostatic and inflammatory conditions, providing a link between mesenteric obesity and inflammation.
  • Conference paper
    Yassin NA, Al-Hassi HO, Lee GH, Malietzis G, Tozer P, Bernardo-Ordiz D, Mann E, Hart A, Knight S, Phillips RKet al., 2013,

    The Aetiology of Crohn’s and Idiopathic Anal Fistulae - Are There Any Differences in the Dendritic Cells Homing Profile?

    , ACPGBI

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