The Genomics Research and meta-Analysis of intrahepatic Cholestasis of prEgnancy (GRACE) consortium, aims to encourage cross-institutional, and collaborative sharing of data. The GRACE consortium aims to facilitate joint analysis of multiple GWAS to identify further genetic loci that are contributing to the aetiology of intrahepatic cholestasis of pregnancy. Through meta-analysis of multiple GWAS, we aim to gain an increased understanding of causal genomic variants and improve health outcomes for women.

GRACE investigators have previously published a GWAS and meta-analyses of three cohorts, identifying 11 loci (GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements | Nature Communications).

Previous work has included the use of Next Generation Sequencing to identify rare genomic variants in ICP (Whole-genome sequencing of patients with rare diseases in a national health system | Nature).

Our investigators have also published a ICP genomic rare variant analysis in underrepresented populations (Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom | Scientific Reports).

Current participating genetic cohorts are described below

We are currently looking for other genetic cohorts that would want to contribute to the GRACE consortium for the next iteration of a multi-ancestry GWAS meta-analyses. To get involved, please fill out this survey regarding information on the data you have that you would like to be included.

Please get in touch for more information or to discuss sharing your data.