Find examples of the types of projects you may do on the different BMR streams:

Projects

General Biomedical Research
  • Advancing epilepsy research: Development of A Novel Analytical Method to Measure Skin-Derived Volatile Organic Compounds
  • Association of placental metabolome with birthweight in pregnancies following bariatric surgery
  • Biochemical characterisation of pathological tau aggregates in neurodegenerative disorders
  • Bionanophotonic Approaches for Discovery of Biomarkers in Early Cancer Detection
  • Designing Artificial Cells for Biomedical Protein Synthesis
  • In vitro and in vivo testing of lipidic nanoparticle formulated for cardiac delivery of RNA therapeutics to heart cells
  • Investigating interactions between reproductive and metabolic hormones in metabolic dysfunction-associated steatotic liver disease (MASLD)
  • Investigating the therapeutic potential of RNA splicing modulation in prostate cancer
  • Lipid metabolism in liver cancer: Unravelling hepatocyte and fibroblast cross-talk
  • Lipidomic, Metabolomic and Proteomic Analyses of Extracellular Vesicles Using Liquid Chromatography-Mass Spectrometry
  • Lipstick-Based Biosensors for Metabolic Monitoring
  • Microrobots for Targeted Cargo Delivery
  • Optimising Scalable Immunological Sampling for Community-Based Pandemic Preparedness
  • Studying Protein Methylation Changes in MTAP-/- Cancer by LC-MS/MS
  • Surface enhanced Raman spectroscopy (SERS) for rapid tumour margin assessment in breast conserving surgery
  • The Role of Neuroinflammation, Gliosis & Neurodegeneration in Blast-traumatic brain injury
  • The use of bimolecular fluorescence complementation to study DDR1 transmembrane interactions
  • Understanding the crosstalk between TREM2 and CD33 in Alzheimer’s disease
  • Using Kisspeptin to investigate the impact of obesity on reproductive health
  • Using live-cell super-resolution microscopy to reveal the dynamics of intra-nuclear proteins in leukemia or epilepsy
Bacterial Pathogenesis and Infection
  • Development of OMV-based vaccine and postbiotic strategies to combat Avian Pathogenic Escherichia coli
  • Dissecting new ways by which host cells respond to attaching and effacing (A/E) pathogens
  • Investigating the interaction of Klebsiella pneumoniae with complement inhibitors
  • Mechanistic insight into newly identified Staphylococcus aureus bacteriophage resistant determinants
  • Single cell microfluidics imaging of mycobacterial interactions with the major mould pathogen Aspergillus fumigatus
  • The evaluation of a Next Generation Sequencing (NGS) method to determine the detection of respiratory pathogens and associated antimicrobial resistance (AMR) markers in clinical samples
  • The molecular basis for polymyxin-murepavadin synergy
  • Understanding how phage-inducible chromosomal islands (PICIs) spread in nature
  • Understanding how resident Pseudomonas species within the airway microbiome impact upon anti-viral immunity in bronchiectasis
  • What is the role of Cardiolipin in the emergent Streptococcus pyogenes lineage M1UK?
Data Science
  • Analysis of whole-genome sequencing data from patients with monogenic conditions
  • Benchmarking AlphaGenome for tissue- and cell-type-specific regulatory variant interpretation in Inflammatory Bowel Disease
  • Comparative transcriptomic analysis of human and feline coronavirus-related inflammatory disease
  • Enhanced Multimodal Chest X-Ray Analysis Using Large Language Models and Vision Transformers
  • Integrating Mass Spectrometry Imaging and Microscopy to evaluate the fidelity of metabolomic spatial pathway analysis.
  • Interpreting Latent Space in Healthcare Foundational Models Using Digital Twins
  • Machine Learning Surrogates for Malaria Vaccine Impact Modelling
  • Mapping Cellular Interactions in IPF through Multi-Modal Imaging and Spatial Analysis
  • Safe Simulation of Pediatric ICU Trajectories with Model-Based Reinforcement Learning
  • Single-cell RNA sequencing  analysis could identify novel therapeutic modalities in IBD intercellular interactions
  • The Influence of Dietary Interventions on Glucose Response in the Context of Type 2 Diabetes Prevention
Epidemiology, Evolution and Control of Infectious Diseases
  • A flexible odin-based SEIR framework for real-time estimation of the effective reproduction number (Rt)
  • Analysing space-time trends in genetic mutations in African mosquito populations that cause resistance to insecticides used in malaria control
  • Can the introduction of an infectious disease during WWII explain the emergence of multiple sclerosis in the Faroe Islands? A modelling study
  • Compensating for Socioeconomic Disparities in Epidemic Outcomes: Modelling Targeted COVID-19 Interventions
  • Linking sequential serology with clinical case data to infer influenza severity in England (with an odin/monty antibody-boosting model)
  • Mathematical modelling approaches to estimate prophylaxis of Plasmodium vivax specific drugs
  • Prevalence, Incidence and Barriers to Seeking Care for Non-Communicable Diseases in a High HIV Prevalence Population in East Zimbabwe
  • Reconstructing malaria transmission trends using prevalence among pregnant women across sub-Saharan Africa
  • Socioeconomic burden of chronic hepatitis B in The Gambia
  • Switching, Mixing, and Epidemic Predictions: quantifying the the effect of dynamic and heterogeneous contact patterns in infectious disease models
  • Uncovering the impact of the epigenome on mobile genetic elements (MGE) in human pathogenic fungi
  • Would Scaled-up Routine Distribution of Insecticide-Treated Bednets be More Impactful Than Mass Campaigns?
Microbiome in Health and Disease
  • Anti-carbohydrate antibodies in rheumatic fever
  • Beyond trafficking: investigating the immunomodulatory role of chemokine receptors in CD4+ T cells
  • Biomolecular condensate studies of nucleosomes and chromatin remodellers
  • Characterizing the effects of HTLV-1 integrase variants on integration
  • Developing engineered bacterial nutrient biosensors as sentinels for gut disease
  • Dissecting neutrophil NET formation in response to clinically invasive strains of Aspergillus fumigatus
  • Epigenomic profiling and functional characterization of neuronal senescence in ageing and neurodegeneration
  • Exploring the role of nanaerobic conditions on mucus foraging by gut bacterial communities
  • Exploring the role of the tumour microenvironment in ovarian cancer progression and resistance to treatment through spatial metabolomics
  • Investigating Transcription Factor Complex Disruption in Inflammatory Bowel Disease to Facilitate Precision Medicine
  • Linking inflammation with age-related sinus node dysfunction
  • Metabolomic profiling and risk of cardiovascular disease
  • Peptide location fingerprinting of mass spectrometry to explore mechanisms and novel biomarker candidates in idiopathic pulmonary fibrosis
  • Polygenic Risk for Type 2 Diabetes Across Diverse Ethnicities
  • Understanding the role of astrocytes in the development of dementia in Parkinson's disease
  • The structure and mechanism of novel Dynamin-like membrane remodelling machines in cancer
  • Using AI-driven de novo protein design and cryoEM to study transcriptional activation mechanism
Molecular Basis of Human Disease
  • Advanced assessment of gut barrier function using fluorescence sensing
  • Bacterial enzymes in the urinary tract microbiome
  • Diet-Antibiotics-Gut bacteria-Host four-way Interaction: exploring the impact of dietary inulin, antibiotics and Klebsiella commensal bacteria on the gastrointestinal health
  • Diet–Infection–Host Interactome: Investigating the Combined Effects of Diet and Citrobacter rodentium Infection on Intestinal Barrier Function and Tissue Metabolism
  • Exploring bacteria-drug interaction in Parkinson's
  • Intestinal epithelial chemistry in colorectal cancer via 3-nitrophenyl derivatisation for Imaging Mass Spectrometry
  • Microbiomes against stress: decoding Akkermansia municiphila’s effect on stress in a clinical trial with SQUAD UHPLC-HRMS metabolomics
  • Microbiome hacks: hippurate as a causal mediator linking the gut microbiome to cardiometabolic health
  • Probiotic Extracellular Vesicles Shape Cell Type Specific Receptor Signalling in Inflammatory Bowel Disease
  • Profiling Conjugated Bile Acids for Translational IBD Research
  • Testing novel anti-biofilm disrupting agents
  • The Influence of Dietary Interventions on Gut Microbiome Composition and Function in the Context of Type 2 Diabetes Prevention
  • Understanding the impact of Neisseria commensals within the airway microbiome upon pulmonary immunity
  • Unravelling the role of the microbiome in cancer risk and cancer therapeutics
Respiratory and Cardiovascular Science
  • Base editing to characterise genetic variants associated with primary lymphoedema
  • Comparative analysis of alveolar epithelium inflammation models in response to bacterial, viral, and fungal infections
  • Design and evaluation of novel polymeric MRI compatible pacemaker lead fixations
  • Effect of phosphodiesterase 4B on cardiac calcium handling under stretch
  • Flow-enhanced organ-on-chip platforms for iPSC-derived microvascular networks
  • Identifying early immunological predictors of subsequent mucosal antibody levels in COVID-19 patients
  • Investigating the lung-brain axis: upper airway inflammation and neuroinflammatory responses to diverse air pollution aerosols
  • Investigating the role of oestrogen in modulating platelet function in women with HIV
  • Modulating cardiomyocyte function through precision disruption of protein interactions
  • Nanomechanics of endothelial cells and its impact on cardiovascular disease
  • Potential of a ‘super-aspirin’ that targets cyclooxygenase enzymes in blood vessels to protect against heart attacks and strokes
  • Real-time AI-enabled macrophage phagocytosis enabled by machine learning
  • Respiratory health in relation to outdoor particulate air pollution in India and Pakistan
  • Understanding the impact of type 1 diabetes and statins on vascular endothelial cell function

You can download a full list of the projects and supervisors for each stream below.

MRes BMR 2025-26 Projects (all streams)