In this section
@article{Decker:2025:10.1080/19490976.2025.2549585,
author = {Decker, V and Qureshi, K and Roberts, L and Powell, N and Marchesi, JR and Mullish, BH and Alexander, JL},
doi = {10.1080/19490976.2025.2549585},
journal = {Gut Microbes},
title = {The emerging role of the gut microbiota in vaccination responses.},
url = {http://dx.doi.org/10.1080/19490976.2025.2549585},
volume = {17},
year = {2025}
}
TY - JOUR
AB - The gut microbiota has emerged as a key modulator of host immune responses, and growing evidence suggests it plays a role in shaping vaccine-induced immunity. While immunization remains vital for preventing infectious diseases, inter-individual variability in vaccine responses poses a persistent challenge. Traditional factors such as age, sex, genetics, and immune status do not fully account for this variability. Recent studies highlight the gut microbiome as a potential contributor. This review examines current evidence linking the gut microbiota to vaccine responses, with a focus on vaccines against SARS-CoV-2, hepatitis B virus, and influenza. Human studies show associations between microbial composition, particularly taxa like Bifidobacterium adolescentis, and immunogenicity. Microbial metabolites, such as short-chain fatty acids and bile acids, influence T-cell differentiation, antibody production, and cytokine responses. Factors that alter microbiota composition, including antibiotics, diet, and prebiotic or probiotic supplementation, can impact vaccine responses, highlighting a dynamic gut-immune relationship. Experimental models further support these observations, showing diminished responses in germ-free or antibiotic-treated animals and enhanced responses following microbial-based interventions. These findings also suggest the gut microbiota may be harnessed to improve vaccine efficacy. Future research should explore the potential for microbiota-targeted strategies to optimize vaccine efficacy, particularly in immunocompromised populations.
AU - Decker,V
AU - Qureshi,K
AU - Roberts,L
AU - Powell,N
AU - Marchesi,JR
AU - Mullish,BH
AU - Alexander,JL
DO - 10.1080/19490976.2025.2549585
PY - 2025///
TI - The emerging role of the gut microbiota in vaccination responses.
T2 - Gut Microbes
UR - http://dx.doi.org/10.1080/19490976.2025.2549585
UR - https://www.ncbi.nlm.nih.gov/pubmed/40884514
VL - 17
ER -
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