In this section
@article{Liu:2026:jcag/gwaf042.036,
author = {Liu, CS and Merrick, B and Taboun, Z and Mullish, B and Kuijper, E and Kao, D},
doi = {jcag/gwaf042.036},
journal = {J Can Assoc Gastroenterol},
title = {Poster Session I - A36 OPTIMIZING AND STANDARDIZING DONOR SCREENING FOR FECAL MICROBIOTA TRANSPLANTATION: A DELPHI REVIEW},
url = {http://dx.doi.org/10.1093/jcag/gwaf042.036},
volume = {9},
year = {2026}
}
TY - JOUR
AB - Fecal microbiota transplantation (FMT) transfers stool from healthy donors to recipients and is highly effective for preventing recurrent Clostridioides difficile infection. However, rare cases of FMT-associated infections have resulted in morbidity and even mortality. Despite the critical importance of screening, evidence-based approaches to developing donor-screening protocols remain limited.This review aimed to evaluate the evidence underpinning current FMT donor screening protocols by critically appraising existing literature on pathogen transmission dynamics.We conducted a comprehensive review up to November 2024. Key factors considered included the geographical distribution of pathogens, likelihood of fecal-oral transmission via FMT, and the clinical consequences of potential transmission events. A Delphi process involving 25 experts in stool banking, donor screening, and FMT preparation and administration was undertaken to establish consensus on the transmissibility of pathogens via FMT, defined as ≥ 80% agreement. Transmission was categorized as definite when supported by documented evidence (e.g., case reports or confirmed donor-to-recipient transmission), possible when fecal-oral transmission was plausible but unconfirmed, and not possible when such transmission was considered unlikely.We identified 58 potentially-relevant pathogens and summarized their prevalence, transmissibility, disease severity, and likelihood of FMT-related transmission (Table 1). This was followed by three rounds of the Delphi process generating 21 consensus statements (Table 2), all achieving a consensus of at least 80% except for SARS-CoV-2 (78%). Although fecal-oral transmission of SARS-CoV-2 is unproven, its detection in stool precluded full consensus. Similarly, hepatitis B, hepatitis C, and HIV showed no evidence of FMT-related transmission, though excluding infected donors remains prudent given potential immune and microbiome alterations. Finally, while CMV i
AU - Liu,CS
AU - Merrick,B
AU - Taboun,Z
AU - Mullish,B
AU - Kuijper,E
AU - Kao,D
DO - jcag/gwaf042.036
PY - 2026///
SN - 2515-2084
TI - Poster Session I - A36 OPTIMIZING AND STANDARDIZING DONOR SCREENING FOR FECAL MICROBIOTA TRANSPLANTATION: A DELPHI REVIEW
T2 - J Can Assoc Gastroenterol
UR - http://dx.doi.org/10.1093/jcag/gwaf042.036
UR - https://doi.org/10.1093/jcag/gwaf042.036
VL - 9
ER -
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