BibTex format
@article{Eriksen:9900,
author = {Eriksen, LL and Støy, S and Hansen, MM and Gatten, EP and Erikstrup, C and Kelsen, J and Mullish, BH and Marchesi, JR and Thomsen, KL and Dahlerup, JF and Dahl, Baumwall SM and Hvas, CL},
journal = {Clinical and Translational Gastroenterology},
title = {Dynamics in circulating immune cell subsets after faecal microbiota transplantation for recurrent Clostridioides difficile infection},
url = {https://journals.lww.com/ctg/fulltext/9900/dynamics_in_circulating_immune_cell_subsets_after.545.aspx},
year = {9900}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Background: Faecal microbiota transplantation (FMT) is effective for recurrent Clostridioides difficile infection (rCDI). Adverse reactions to FMT occur early, and cellular immune responses after FMT may contribute to effects and reactions. We compared early changes in peripheral immune cell subsets and clinical outcomes in patients with rCDI who received either FMT and antibiotics or antibiotics alone in a randomized trial. Methods: Thirty-five patients with rCDI were randomized to vancomycin and FMT (n=20) or vancomycin alone (n=15). Blood samples were drawn before (wk0) and one week (wk1) after treatment. In three additional patients, blood samples were drawn before, and 24 hours and wk1 after FMT. Adaptive and innate immune cell subsets and gut-homing memory (CD45RO+integrinβ7+) and effector (CD45RO-integrinβ7+) T cells were analysed by flow cytometry. Results: FMT induced subtle changes in immune cell subsets with no clear pattern from wk0 to wk1. The Treg fraction tended to decrease after FMT, and a similar decrease at 24 hours indicated rapid Tregs dynamics. NKT cells increased during the first 24 hours and returned to baseline level at wk1. Regardless of FMT, patients with clinical resolution from rCDI had a decrease in non-classical monocytes and a shift in gut-homing memory to effector cells at wk1. Conclusion: In rCDI, FMT induced subtle and transient dynamics in peripheral immune cell subsets. Tregs and NKT cells seemed responsive and should be further studied. Cure of CDI may be associated with an increase in circulating gut-homing T cells. © 2026 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology
AU - Eriksen,LL
AU - Støy,S
AU - Hansen,MM
AU - Gatten,EP
AU - Erikstrup,C
AU - Kelsen,J
AU - Mullish,BH
AU - Marchesi,JR
AU - Thomsen,KL
AU - Dahlerup,JF
AU - Dahl,Baumwall SM
AU - Hvas,CL
PY - 9900///
SN - 2155-384X
TI - Dynamics in circulating immune cell subsets after faecal microbiota transplantation for recurrent Clostridioides difficile infection
T2 - Clinical and Translational Gastroenterology
UR - https://journals.lww.com/ctg/fulltext/9900/dynamics_in_circulating_immune_cell_subsets_after.545.aspx
ER -