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@article{McDowell:2024:10.1111/jns.12645,
author = {McDowell, AR and Zambreanu, L and Salhab, HA and Doherty, CM and Bridgen, P and Lally, P and Shah, S and Huo, Z and Wastling, SJ and Yousry, T and Morrow, J and Thornton, JS and Lunn, MP},
doi = {10.1111/jns.12645},
journal = {Journal of the Peripheral Nervous System},
pages = {368--375},
title = {Initial findings using high-resolution magnetic resonance imaging for visualisation of the sural nerve and surrounding anatomy in healthy volunteers at 7 Tesla},
url = {http://dx.doi.org/10.1111/jns.12645},
volume = {29},
year = {2024}
}

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TY  - JOUR
AB  - Background and AimsHistopathological diagnosis is the gold standard in many acquired inflammatory, infiltrative and amyloid based peripheral nerve diseases and a sensory nerve biopsy of sural or superficial peroneal nerve is favoured where a biopsy is deemed necessary. The ability to determine nerve pathology by high-resolution imaging techniques resolving anatomy and imaging characteristics might improve diagnosis and obviate the need for biopsy in some. The sural nerve is anatomically variable and occasionally adjacent vessels can be sent for analysis in error. Knowing the exact position and relationships of the nerve prior to surgery could be clinically useful and thus reliably resolving nerve position has some utility.Methods7T images of eight healthy volunteers' (HV) right ankle were acquired in a pilot study using a double-echo in steady-state sequence for high-resolution anatomy images. Magnetic Transfer Ratio images were acquired of the same area. Systematic scoring of the sural, tibial and deep peroneal nerve around the surgical landmark 7 cm from the lateral malleolus was performed (number of fascicles, area in voxels and mm2, diameter and location relative to nearby vessels and muscles).ResultsThe sural and tibial nerves were visualised in the high-resolution double-echo in steady-state (DESS) image in all HV. The deep peroneal nerve was not always visualised at level of interest. The MTR values were tightly grouped except in the sural nerve where the nerve was not visualised in two HV. The sural nerve location was found to be variable (e.g., lateral or medial to, or crossing behind, or found positioned directly posterior to the saphenous vein).InterpretationHigh-resolution high-field images have excellent visualisation of the sural nerve and would give surgeons prior knowledge of the position before surgery. Basic imaging characteristics of the sural nerve can be acquired, but more detailed imaging characteristics are not easily evaluable in the v
AU  - McDowell,AR
AU  - Zambreanu,L
AU  - Salhab,HA
AU  - Doherty,CM
AU  - Bridgen,P
AU  - Lally,P
AU  - Shah,S
AU  - Huo,Z
AU  - Wastling,SJ
AU  - Yousry,T
AU  - Morrow,J
AU  - Thornton,JS
AU  - Lunn,MP
DO  - 10.1111/jns.12645
EP  - 375
PY  - 2024///
SN  - 1085-9489
SP  - 368
TI  - Initial findings using high-resolution magnetic resonance imaging for visualisation of the sural nerve and surrounding anatomy in healthy volunteers at 7 Tesla
T2  - Journal of the Peripheral Nervous System
UR  - http://dx.doi.org/10.1111/jns.12645
VL  - 29
ER  -

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