In this section
@article{Schweitzer:2025,
author = {Schweitzer, R and de, Marvao A and Shah, M and Inglese, P and Kellman, P and Berry, A and Statton, B and O'Regan, D},
journal = {Radiology: Cardiothoracic Imaging},
title = {Establishing cardiac MRI reference ranges stratified by sex and age for cardiovascular function during exercise},
year = {2025}
}
TY - JOUR
AB - Purpose: To evaluate the effects of exercise on left ventricular parameters using exercise cardiac MRI in healthy adults without known cardiovascular disease, and establish reference ranges stratified by age and sex.Materials and Methods: This prospective study included healthy adult participants with no known cardiovascular disease or genetic variants associated with cardiomyopathy, enrolled between January 2018 and April 2021, who underwent exercise cardiac MRI evaluation. Participants were imaged at rest and after exercise, with parameters measured by two readers. Prediction intervals were calculated and compared across sex and age groups.Results: The study included 161 participants (mean age, 49±[SD]14 years; 85 female). Compared with the resting state, exercise caused an increase in heart rate (64±9 bpm vs 133±19 bpm, P < 0.001), left ventricular end-diastolic volume (140±32 ml vs 148±35 ml, P < 0.001), stroke volume (82±18 ml vs 102±25 ml, P < 0.001), ejection fraction (59±6% vs 69±7%, P < 0.001), and cardiac output (5.2±1.1 l/min vs 13.5±3.9 l/min, P < 0.001), and a decrease in left ventricular end-systolic volume (58±18 ml vs 46±15 ml, P < 0.001). There were significant differences in exercise response between groups stratified by sex and age for most parameters.Conclusion: In healthy adults, an increase in cardiac output after exercise is driven by a rise in heart rate with both increased ventricular filling and emptying. Normal ranges for exercise response, stratified by age and sex, are established as a reference for the use of exercise cardiac MRI in clinical practice.
AU - Schweitzer,R
AU - de,Marvao A
AU - Shah,M
AU - Inglese,P
AU - Kellman,P
AU - Berry,A
AU - Statton,B
AU - O'Regan,D
PY - 2025///
SN - 2638-6135
TI - Establishing cardiac MRI reference ranges stratified by sex and age for cardiovascular function during exercise
T2 - Radiology: Cardiothoracic Imaging
ER -
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