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@article{Khalique:2025:10.1161/CIRCIMAGING.125.018226,
author = {Khalique, Z and Scott, AD and Ferreira, PF and Molto, M and Nielles-Vallespin, S and Pennell, DJ},
doi = {10.1161/CIRCIMAGING.125.018226},
journal = {Circ Cardiovasc Imaging},
title = {Diffusion Tensor CMR Assessment of the Microstructural Response to Dobutamine Stress in Health and Comparison With Patients With Recovered Dilated Cardiomyopathy.},
url = {http://dx.doi.org/10.1161/CIRCIMAGING.125.018226},
year = {2025}
}

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TY  - JOUR
AB  - BACKGROUND: Contractile reserve assessment assesses myocardial performance and prognosis. The microstructural mechanisms that facilitate increased cardiac function have not been described, but can be studied using diffusion tensor cardiovascular magnetic resonance. Resting microstructural contractile function is characterized by reorientation of aggregated cardiomyocytes (sheetlets) from wall-parallel in diastole to a more wall-perpendicular configuration in systole, with the diffusion tensor cardiovascular magnetic resonance parameter E2A defining their orientation, and sheetlet mobility defining the angle through which they rotate. We used diffusion tensor cardiovascular magnetic resonance to identify the microstructural response to dobutamine stress in healthy volunteers and then compared with patients with recovered dilated cardiomyopathy (rDCM). METHODS: In this first-of-its-kind prospective observational study, 20 healthy volunteers and 32 patients with rDCM underwent diffusion tensor cardiovascular magnetic resonance at rest, during dobutamine, and on recovery. RESULTS: In healthy volunteers, both diastolic and systolic E2A increased with dobutamine stress (13±3° to 17±5°; P<0.001 and 59±11° to 65±7°; P=0.002). Sheetlet mobility remained unchanged (45±11° to 49±10°; P=0.19), but biphasic mean E2A increased (36±6° to 41±4°; P<0.001). In rDCM, diastolic E2A at rest was higher than in healthy volunteers (20±8° versus 13±3°, P<0.001), and sheetlet mobility was reduced (34±12° versus 45±11°; P<0.001). During dobutamine stress, rDCM diastolic and systolic E2A increased compared with rest (20±8° to 24±10°; P=0.001 and 54±13° to 63±11°; P=0.005). However, sheetlet mobility in patients with rDCM failed to increase with dobutamine to healthy levels (39±13° versus 49±
AU  - Khalique,Z
AU  - Scott,AD
AU  - Ferreira,PF
AU  - Molto,M
AU  - Nielles-Vallespin,S
AU  - Pennell,DJ
DO  - 10.1161/CIRCIMAGING.125.018226
PY  - 2025///
TI  - Diffusion Tensor CMR Assessment of the Microstructural Response to Dobutamine Stress in Health and Comparison With Patients With Recovered Dilated Cardiomyopathy.
T2  - Circ Cardiovasc Imaging
UR  - http://dx.doi.org/10.1161/CIRCIMAGING.125.018226
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41384329
ER  -

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