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@article{McGill:2012:10.1186/1532-429X-14-86,
author = {McGill, L-A and Ismail, TF and Nielles-Vallespin, S and Ferreira, P and Scott, AD and Roughton, M and Kilner, PJ and Ho, SY and McCarthy, KP and Gatehouse, PD and others},
doi = {10.1186/1532-429X-14-86},
journal = {Journal of Cardiovascular Magnetic Resonance},
pages = {86--86},
title = {Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy},
url = {http://dx.doi.org/10.1186/1532-429X-14-86},
volume = {14},
year = {2012}
}

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TY  - JOUR
AB  - Background: Myocardial disarray is an important histological feature of hypertrophic cardiomyopathy (HCM) whichhas been studied post-mortem, but its in-vivo prevalence and extent is unknown. Cardiac Diffusion Tensor Imaging(cDTI) provides information on mean intravoxel myocyte orientation and potentially myocardial disarray. Recenttechnical advances have improved in-vivo cDTI, and the aim of this study was to assess the interstudyreproducibility of quantitative in-vivo cDTI in patients with HCM.Methods and results: A stimulated-echo single-shot-EPI sequence with zonal excitation and parallel imaging wasimplemented. Ten patients with HCM were each scanned on 2 different days. For each scan 3 short axismid-ventricular slices were acquired with cDTI at end systole. Fractional anisotropy (FA), mean diffusivity (MD), andhelix angle (HA) maps were created using a cDTI post-processing platform developed in-house. The mean ± SDglobal FA was 0.613 ± 0.044, MD was 0.750 ± 0.154 × 10-3 mm2/s and HA was epicardium −34.3 ± 7.6°,mesocardium 3.5 ± 6.9° and endocardium 38.9 ± 8.1°. Comparison of initial and repeat studies showed globalinterstudy reproducibility for FA (SD = ± 0.045, Coefficient of Variation (CoV) = 7.2%), MD (SD = ± 0.135 × 10-3 mm2/s,CoV = 18.6%) and HA (epicardium SD = ± 4.8°; mesocardium SD = ± 3.4°; endocardium SD = ± 2.9°). Reproducibilityof FA was superior to MD (p = 0.003). Global MD was significantly higher in the septum than the reference lateralwall (0.784 ± 0.188 vs 0.750 ± 0.154 x10-3 mm2/s, p < 0.001). Septal HA was significantly lower than the referencelateral wall in all 3 transmural layers (from −8.3° to −10.4°, all p < 0.001).Conclusions: To the best of our knowledge, this is the first study to assess the interstudy reproducibility of DTI inthe human HCM heart in-vivo and the largest cDTI stu
AU  - McGill,L-A
AU  - Ismail,TF
AU  - Nielles-Vallespin,S
AU  - Ferreira,P
AU  - Scott,AD
AU  - Roughton,M
AU  - Kilner,PJ
AU  - Ho,SY
AU  - McCarthy,KP
AU  - Gatehouse,PD
AU  - others
DO  - 10.1186/1532-429X-14-86
EP  - 86
PY  - 2012///
SN  - 1097-6647
SP  - 86
TI  - Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy
T2  - Journal of Cardiovascular Magnetic Resonance
UR  - http://dx.doi.org/10.1186/1532-429X-14-86
UR  - https://jcmr-online.biomedcentral.com/articles/10.1186/1532-429X-14-86
VL  - 14
ER  -

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