In this section
@article{Deane:2020:10.1186/s12891-020-03346-7,
author = {Deane, JA and Pavlova, A and Lim, A and Gregory, J and Aspden, R and McGregor, A},
doi = {10.1186/s12891-020-03346-7},
journal = {BMC Musculoskeletal Disorders},
pages = {1--10},
title = {Is intrinsic lumbar spine shape associated with Lumbar Disc Degeneration? An exploratory study},
url = {http://dx.doi.org/10.1186/s12891-020-03346-7},
volume = {21},
year = {2020}
}
TY - JOUR
AB - Background: Lumbar disc degeneration (LDD) is a condition associated with recurrentlow back pain (LBP). Knowledge regarding effective management is limited. As a steptowards the identification of risk, prognostic or potentially modifiable factors in LDDpatients, the aim of this study was to explore the hypothesis that intrinsic lumbar spineshape is associated with LDD and clinical outcomes in symptomatic adults. Methods: 3T MRI was used to acquire T2-weighted sagittal images (L1-S1) from 70healthy controls and LDD patients (mean age 49 years, SD 11, range 31-71years). Statistical Shape Modelling (SSM) was used to describe lumbar spine shape.SSM identified variations in lumbar shape as ‘modes’ of variation and quantifieddeviation from the mean. Intrinsic shape differences were determined between LDDgroups using analysis of variance with post-hoc comparisons. The relationshipbetween intrinsic shape and self-reported function, mental health and quality of lifewere also examined.Results: The first 7 modes of variation explained 91% of variance in lumbarshape. Higher LDD sum scores correlated with a larger lumbar lordosis (Mode 1 (55%variance), P=0.02), even lumbar curve distribution (Mode 2 (12% variance), P=0.05),larger anterior-posterior (A-P) vertebral diameter (Mode 3 (10% variance), P=0.007)and smaller L4-S1 disc spaces (Mode 7 (2% variance), P≤0.001). In the presence ofrecurrent LBP, LDD was associated with a larger A-P vertebral diameter (Mode 3) anda more even lumbar curvature with smaller L5/S1 disc spaces (Mode 4), which wassignificantly associated with patient quality of life (P=0.002-0.04, r p =0.43-0.61)).Conclusions: This exploratory study provides new evidence that intrinsic shapephenotypes are associated with LDD and quality of life in patients. Longitudinalstudies are required to establish the potential role of these risk or prognostic shapephenotypes.
AU - Deane,JA
AU - Pavlova,A
AU - Lim,A
AU - Gregory,J
AU - Aspden,R
AU - McGregor,A
DO - 10.1186/s12891-020-03346-7
EP - 10
PY - 2020///
SN - 1471-2474
SP - 1
TI - Is intrinsic lumbar spine shape associated with Lumbar Disc Degeneration? An exploratory study
T2 - BMC Musculoskeletal Disorders
UR - http://dx.doi.org/10.1186/s12891-020-03346-7
UR - https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-020-03346-7
VL - 21
ER -