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@article{Bonicelli:2023:10.1016/j.jmbbm.2022.105573,
author = {Bonicelli, A and Tay, T and Cobb, JP and Boughton, OR and Hansen, U and Abel, RL and Zioupos, P},
doi = {10.1016/j.jmbbm.2022.105573},
journal = {Journal of the Mechanical Behavior of Biomedical Materials},
title = {Association between nanoscale strains and tissue level nanoindentation properties in age-related hip-fractures},
url = {http://dx.doi.org/10.1016/j.jmbbm.2022.105573},
volume = {138},
year = {2023}
}
TY - JOUR
AB - Measurement of the properties of bone as a material can happen in various length scales in its hierarchical and composite structure. The aim of this study was to test the tissue level properties of clinically-relevant human bone samples which were collected from donors belonging to three groups: ageing donors who suffered no fractures (Control); untreated fracture patients (Fx-Untreated) and patient who experienced hip fracture despite being treated with bisphosphonates (Fx-BisTreated). Tissue level properties were assessed by (a) nanoindentation and (b) synchrotron tensile tests (STT) where strains were measured at the ‘tissue’, ‘fibril’ and ‘mineral’ levels by using simultaneous Wide-angle - (WAXD) and Small angle- X-ray diffraction (SAXD). The composition was analysed by thermogravimetric analysis and material level endo- and exo-thermic reactions by differential scanning calorimetry (TGA/DSC3+). Irrespective of treatment fracture donors exhibited significantly lower tissue, fibril and mineral strain at the micro and nanoscale respectively and had a higher mineral content than controls. In nanoindentation only nanohardness was significantly greater for Controls and Fx-BisTreated versus Fx-Untreated. The other nanoindentation parameters did not vary significantly across the three groups. There was a highly significant positive correlation (p < 0.001) between organic content and tissue level strain behaviour. Overall hip-fractures were associated with lower STT nanostrains and it was behaviour measured by STT which proved to be a more effective approach for predicting fracture risk because evidently it was able to demonstrate the mechanical deficit for the bone tissue of the donors who had experienced fractures.
AU - Bonicelli,A
AU - Tay,T
AU - Cobb,JP
AU - Boughton,OR
AU - Hansen,U
AU - Abel,RL
AU - Zioupos,P
DO - 10.1016/j.jmbbm.2022.105573
PY - 2023///
SN - 1751-6161
TI - Association between nanoscale strains and tissue level nanoindentation properties in age-related hip-fractures
T2 - Journal of the Mechanical Behavior of Biomedical Materials
UR - http://dx.doi.org/10.1016/j.jmbbm.2022.105573
UR - https://www.sciencedirect.com/science/article/pii/S1751616122004787?via%3Dihub
VL - 138
ER -