In this section
@inbook{Kaufmann:2023:10.1007/978-3-031-10355-1_44,
author = {Kaufmann, JJ and McMenemy, L and Phillips, ATM and McGregor, AH},
booktitle = {Blast Injury Science and Engineering A Guide for Clinicians and Researchers Second Edition},
doi = {10.1007/978-3-031-10355-1_44},
pages = {479--488},
title = {Bone Health in Lower-Limb Amputees},
url = {http://dx.doi.org/10.1007/978-3-031-10355-1_44},
year = {2023}
}
TY - CHAP
AB - Bone mineral density (BMD) loss in lower-limb amputees has in the past been referred to as either osteopenia or osteoporosis. However, evidence and hypotheses in emerging literature are beginning to challenge this, suggesting that the use of these terms could be inappropriate due to key differences in the aetiology and mechanisms underpinning the bone loss in the younger amputee population. Computational and clinical analysis carried out within the Centre for Blast Injury Studies at Imperial College London and the ADVANCE Study has provided strong evidence to support this stance. Investigating BMD discordance in the spine and femur of 153 lower-limb amputees and a frequency-matched control population has shown that bone loss in amputees is localised to the amputated limb rather than systemic (as it manifests in age-related osteoporosis). Combined musculoskeletal and finite element modelling goes some way to explaining the cause of this. Weight bearing through a prosthetic socket offloads the distal femur, and consequently large areas of the femoral shaft and neck experience significantly reduced levels of stimulation when compared to weight bearing on a healthy limb. The long-term result of this is a phenomenon that we refer to as unloading osteopenia.
AU - Kaufmann,JJ
AU - McMenemy,L
AU - Phillips,ATM
AU - McGregor,AH
DO - 10.1007/978-3-031-10355-1_44
EP - 488
PY - 2023///
SP - 479
TI - Bone Health in Lower-Limb Amputees
T1 - Blast Injury Science and Engineering A Guide for Clinicians and Researchers Second Edition
UR - http://dx.doi.org/10.1007/978-3-031-10355-1_44
ER -