BibTex format
@article{Hollmann:2025:10.1016/j.bja.2025.01.034,
author = {Hollmann, VC and Darwood, ARJ and Sarai, PS and Strutton, PH and Harrop-Griffiths, W and Mullington, CJ},
doi = {10.1016/j.bja.2025.01.034},
journal = {British Journal of Anaesthesia},
pages = {1341--1349},
title = {Psychomotor Responses to Independent Visual, Auditory and Tactile Electrical stimuli during Sevoflurane sedation (PRIVATES)},
url = {http://dx.doi.org/10.1016/j.bja.2025.01.034},
volume = {134},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundPatient-controlled sedation has potential benefits, including rapid recovery and improved patient satisfaction. During patient-controlled sedation, the recipient presses a button to self-administer the sedative. The safety and efficacy of this method is dependent upon the dose relationships between the sedative's desired effects, its impact on the ability to press a button, and adverse effect occurrence. This study aimed to investigate the relationship between sedation, psychomotor function, and adverse effect occurrence during clinician-controlled sevoflurane sedation.Methods15 healthy participants (10 males) were administered a sevoflurane dose-escalation protocol starting at 0 kPa and increasing in 0.2 kPa increments until a protocol endpoint occurred. Sevoflurane was delivered using conventional anaesthetic apparatus. At each sevoflurane dose, Richmond Agitation-Sedation Scale (RASS) and psychomotor function were assessed. Protocol endpoints included airway, respiratory, or cardiovascular compromise; agitation (RASS ≥+2); and sedation >3 h.ResultsThe protocol endpoint was sedation >3 h for nine (60%) participants, agitation for five (33%) participants, and tonic movements for one (7%) participant. The median [range] sevoflurane dose was 0.4 [0.2–1.0] kPa when RASS <0 (sedation dose), 1.2 [0.6–2.0] kPa when participants were unable to complete reaction time testing (button-press dose), and 1.6 [1.2–2.2] kPa at the protocol endpoint (endpoint dose). The sedation dose was less than the button-press dose (P<0.0001), and the button-press dose was less than the endpoint dose (P=0.002).ConclusionsPatient-controlled sevoflurane sedation is potentially feasible in a healthy population within the dose range 0.4–1.2 kPa. Concurrent reaction time monitoring could minimise the risk of agitation.
AU - Hollmann,VC
AU - Darwood,ARJ
AU - Sarai,PS
AU - Strutton,PH
AU - Harrop-Griffiths,W
AU - Mullington,CJ
DO - 10.1016/j.bja.2025.01.034
EP - 1349
PY - 2025///
SN - 0007-0912
SP - 1341
TI - Psychomotor Responses to Independent Visual, Auditory and Tactile Electrical stimuli during Sevoflurane sedation (PRIVATES)
T2 - British Journal of Anaesthesia
UR - http://dx.doi.org/10.1016/j.bja.2025.01.034
UR - https://doi.org/10.1016/j.bja.2025.01.034
VL - 134
ER -