Selected publications

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Publicatons 2025

Nanoscale restructuring of the immune synapse with an engager enhances NK cell function. Hazime KS, Sheppard S, Niembro-Vivanco O et al. PNAS (2025) 122 (38), e2507336122. DOI:10.1073/pnas.2507336122

citrOgen: a synthesis-free polysaccharide and protein antigen-presentation to antibody-induction platform. Wong JLC, Sanchez-Garrido J, Rattle J, et al. Nat. Comm. (2025) 16, 8886. DOI: 10.1073/pnas.250733612

Severe asthma is characterized by a sex-specific ILC landscape and aberrant airway profile that is suppressed by anti–IL-5/5Rα biologics. Mincham KT, Loewenthal LE, Meyer GFM, et al. Sci. Transl.  Med. (2025) 17,eadu4913. DOI:10.1126/scitranslmed.adu4913

Investigating the Impact of NKG2D Ligands in Natural Killer Cell- Tumour Cell Interactions. Ozkan O (2025). PhD thesis. Imperial College London.

Publicatons 2024

NK cell subsets define sustained remission in rheumatoid arthritis. Coyle C, Ma M, Abraham Y, et al. JCI Insights (2024), 9(23):e182390. DOI: 10.1172/jci.insight.182390

Investigating the intestinal pathogenesis and immunity induced by C. rodentium. Oliveira de Vasconcelos R (2024). PhD thesis. Imperial College London.

Label retaining haematopoietic stem cells preserve their stemness during Plasmodium berghei infection and maintain low metabolic statuses. Georgiou C (2024). PhD thesis. Imperial College London.

Publicatons 2023

Exploring the cellular response to acute mechanical force for intracellular delivery and cell therapy applications. McCandless M (2023). PhD thesis. Imperial College London.

Dissecting the effects of acute myeloid leukaemia and chemotherapy on the HSC and the niche: on the road to haematopoietic recovery. Gonzalez Anton S (2023). PhD thesis. Imperial College London.

Engineering the NK cell cancer immune response using biofunctionalised nanographene oxide. Dodd H (2023). PhD thesis. Imperial College London.

Growth Arrest of Staphylococcus aureus Induces Daptomycin Tolerance via Cell Wall Remodelling. Ledger EVK and Edwards AM. mBio (2023). DOI:10.1128/mbio.03558-22

OMIP-086: Full spectrum flow cytometry for high-dimensional immunophenotyping of mouse innate lymphoid cells. Mincham K and Snelgrove R. Cytometry Part A (2023), 103 (2): 110-116 . DOI: 10.1002/cyto.a.24702

A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Yahiya S, Saunders CN, Hassan S, et al. Dis Model Mech (2023), 16 (2): dmm049950. DOI: 10.1242/dmm.049950

Publicatons 2022

Enhanced immune responses following heterologous vaccination with self-amplifying RNA and mRNA COVID-19 vaccines. Elliot T, Cheeseman HM, Evans AB, et al. PLoS Pathogens (2022), 18 (10): e1010885 . DOI: 10.1371/journal.ppat.1010885

Matrix metalloproteinase-12 supports pulmonary B cell follicle formation and local antibody responses during asthma. Pyle CJ, Patel DF, Peiró T, et al. Am J Res and Crit Care Med (2022), 206 (11):1424-1428. DOI: 10.1164/rccm.202109-2082LE

Temporal profiling of CD4 T-cell activation and differentiation upon SARS-CoV-2 spike protein immunisation. Almeida-Santos J, Berkachy R, Tye CA, et al. bioRxiv (2022) 2022.07.21.500987. DOI: 10.1101/2022.07.21.500987

Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae. David S, Wong JLC, Sanchez-Garrido J, et al. PLOS Pathogens (2022), 18 (7): e1010334. DOI: 10.1371/journal.ppat.1010334

Block length-dependent protein fouling on poly(2-oxazoline)-based polymersomes: influence on macrophage association and circulation behavior. Najer A, Belessiotis-Richards A, Kim H, et al. Small (2022), 18: 2201993. DOI: 10.1002/smll.202201993

Emergent expression of fitness-conferring genes by phenotypic selection. Ciechonska M, Sturrock M, Grob A, et al. PNAS Nexus (2022), 1 (3): pgac069. DOI:10.1093/pnasnexus/pgac069

Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness. Pirillo C, Birch F, Tissot FS, et al. Blood Adv (2022), 6 (10): 3126–3141. DOI: 10.1182/bloodadvances.2021004321

NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. Curio S, Edwards SC, Suzuki T, et al. Discovery Immunology (2022), 1 (1): kyac002 . DOI: 10.1093/discim/kyac002

Potent Virustatic Polymer–Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo. Najer A, Blight J, Ducker C, et al. ACS Cent Sci (2022), 8 (9): 1238–1257 . DOI:10.1021/acscentsci.1c01368

The Salmonella transmembrane effector SteD hijacks AP1-mediated vesicular trafficking for delivery to antigen-loading MHCII compartments. Godlee C, Cerny O, Liu M, et al. PLOS Pathogens (2022), 18 (5): e1010252 . DOI: 10.1371/journal.ppat.1010252

Bacterial Toxin-Triggered Release of Antibiotics from Capsosomes Protects a Fly Model from Lethal Methicillin-Resistant Staphylococcus aureus (MRSA) Infection. Tonkin RL, Klöckner A, Adrian Najer A, et al. Adv Healthcare Mater (2022), 11: 2200036 . DOI: 10.1002/adhm.202200036

In Vitro Development of Mouse and Human NK Cells from Hematopoietic Progenitor Cells. Ullmo I, Koksal N, Ang HYK, Brady HJM. Natural Killer (NK) Cells (2022): 31-45. DOI: 10.1007/978-1-0716-2160-8_3.

Citrobacter rodentium infection induces persistent molecular changes and interferon gamma-dependent major histocompatibility complex Class II expression in the colonic epithelium. Mullineaux-Sanders C, Kozik Z, Sanchez-Garrido J, et al. mBio (2022), 13 (1): e03233-21 . DOI: 10.1128/mbio.03233-21.

Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVD-19 respiratory disease. Vijayakumar B, Boustani K, Ogger P, et al. Immunity (2022). DOI: 10.1016/j.immuni.2022.01.017.

Publicatons 2021

Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity. Pyle C, Labeur-Iurman L, Groves HT, et al. J Exp Med (2021), 218 (12): e20201555 . DOI: 10.1084/jem.20201555

Novel aspects of iron homeostasis in pathogenic bloodstream form Trypanosoma brucei. Gilabert Carbajo C, Cornell LJ, Madbouly Y, et al. PLoS Pathogens (2021), 17 (6): e1009696 . DOI: 10.1371/journal.ppat.1009696

A single-cell atlas of Plasmodium falciparum transmission through the mosquito. Real E, Howick VM, Dahalan FA, et al. Nat Commun (2021) 12: 3196 . DOI: 10.1038/s41467-021-23434-z

Type III secretion system effectors form robust and flexible intracellular virulence networks. Ruano-Gallego D, Sanchez-Garrido J, Kozik Z, et al. Science (2021), 371 (6534): eabc9531 . DOI: 10.1126/science.abc9531

Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths. Roberts LB, Schnoeller C, Berkachy R, et al. Science Immunology (2021), 5; 6 (57): eabd0359 . DOI: 10.1126/sciimmunol.abd0359

Publicatons 2020

Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection. Haltalli MLR, Watcham S, Wilson NK, et al. Nat Cell Biol (2020), 22: 1399–1410 . DOI: 10.1038/s41556-020-00601-w

Publicatons 2019

A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma. Branchett WJ, Stölting H, Oliver RA, et al. J Allergy Clin Immunol (2019), 145 (2): 666‐678.e9 . DOI: 10.1016/j.jaci.2019.08.006

Publicatons 2018

Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites. Lyth O, Vizcay-Barrena G, Wright KE, et al. Sci Rep (2018). 8: 10165 . DOI: 10.1038/s41598-018-28457-z