A review of Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates is published
Joshua Almond-Thynne David C. Blakemore, David C. Pryde and Alan C. Spivey, 'Site-selective Suzuki-Miyaura Coupling of Heteroaryl Halides - Understanding the Trends for Pharmaceutically Important Cases', Chem. Sci. 2017, 8, 40 - 62. DOI: 10.1039/C6SC02118B
Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer’s global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.
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Professor Alan C Spivey
Department of Chemistry
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Tel: +44 (0)20 7594 5841
Email: a.c.spivey@imperial.ac.uk
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