Imperial College London

Oct 2019 - Article in J. Org. Chem. Published

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J. Org. Chem. Cover Image

Chris Nielsen's paper on the Hydroarylation of alkenes by protonation/Friedel-Crafts trapping is published.

Christian D.-T. Nielsen, Andrew J. P. White, David Sale, Jordi Burés and Alan Christopher Spivey, 'Hydroarylation of alkenes by protonation/Friedel-Crafts trapping – HFIP-mediated access to per-aryl quaternary stereocentres' J. Org. Chem. 2019, 84, 4965-14973, DOI: 10.1021/acs.joc.9b02393

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Upon treatment with a combination of HFIP and an organic sulfonic acid, alkenes behave as Brønsted bases and protonate to give carbocations which can be trapped by electron-rich arenes. The reaction constitutes a Friedel-Crafts (FC) hydroarylation which proceeds with Markovnikov selectivity and is orthogonal to traditional metal-catalyzed processes. Intermolecular transfer hydrogenation and hydrothiolation under analogous conditions are also demonstrated.

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Professor Alan C Spivey

Professor Alan C Spivey
Department of Chemistry

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Tel: +44 (0)20 7594 5841
Email: a.c.spivey@imperial.ac.uk

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Christian Nielsen

Christian Nielsen
Department of Chemistry

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Email: press.office@imperial.ac.uk
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