Imperial College London

Review in RSC Chemical Biology


Inhibition of PPIs in Bacteria

Our review on Modulators of Protein-Protein Interactions as Antimicrobial Agents is now online at RSC Chemical Biology

Our review article entitled 'Modulators of Protein-Protein Interactions as Antimicrobial Agents' is now online at RSC Chemical Biology

Protein–Protein interactions (PPIs) are involved in a myriad of cellular processes in all living organisms and the modulation of PPIs is already under investigation for the development of new drugs targeting cancers, autoimmune diseases and viruses. PPIs are also involved in the regulation of vital functions in bacteria and, therefore, targeting bacterial PPIs offers an attractive strategy for the development of antibiotics with novel modes of action. The latter are urgently needed to tackle multidrug-resistant and multidrug-tolerant bacteria. In this review, we describe recent developments in the modulation of PPIs in pathogenic bacteria for antibiotic development, including advanced small molecule and peptide inhibitors acting on bacterial PPIs involved in division, replication and transcription, outer membrane protein biogenesis, with an additional focus on toxin–antitoxin systems as upcoming drug targets.

This article is part of a themed collection: RSC Chemical Biology Transparent Peer Review. The reviewers comments and our response are published alongside our final review article.

Congratulations to Rashi, Dennis, Guilherme and Simon!


Anna Barnard

Anna Barnard
Department of Chemistry

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