Jan 2022 - Article Published in Org. Biomol. Chem.

Chris Nielsen, Josh Linfoot and Alex Williams' review of Synergistic Catalysis is published in Org. Biomol. Chem.

C. Neilsen, J. Linfoot, A. Williams and A.C Spivey, ‘Synergistic catalysis - The judicious combination of selected chiral organocatalysts with achiral metal catalysts’ Org. Biomol. Chem. 2022, 20, 2764-2778. DOI: https://doi.org/10.1039/D2OB00025C

In this review we survey recent synergistic applications of a chiral organocatalyst with an achiral metal to perform stereoselective transformations of synthetic utility (since 2016). The transformations are classified by the modes of reactivity deployed, focussing on organocatalytic activation of carbonyl substrates as chiral nucleophiles via the α-position (e.g., as enamines) and as chiral electrophiles via the β-position (e.g., as iminium ions) combined with complementary activation of their reaction partners by an achiral metal co-catalyst (e.g., Pd or Cu-based). Corresponding radical reactions are also presented in which photocatalysis mediated by achiral metal complexes replaces the metal co-catalyst. Certain privileged structures are revealed and opportunities to develop this exciting field are highlighted.