Search or filter publications

Filter by type:

Filter by publication type

Filter by year:



  • Showing results for:
  • Reset all filters

Search results

  • Journal article
    Walter B, Pruessner G, Salbreux G, 2022,

    Field theory of survival probabilities, extreme values, first-passage times, and mean span of non-Markovian stochastic processes

    , Physical Review Research, Vol: 4, Pages: 1-21, ISSN: 2643-1564

    We provide a perturbative framework to calculate extreme events ofnon-Markovian processes, by mapping the stochastic process to a two-speciesreaction diffusion process in a Doi-Peliti field theory combined with theMartin-Siggia-Rose formalism. This field theory treats interactions and theeffect of external, possibly self-correlated noise in a perturbation about aMarkovian process, thereby providing a systematic, diagrammatic approach toextreme events. We apply the formalism to Brownian Motion and calculate itssurvival probability distribution subject to self-correlated noise.

  • Working paper
    Cocconi L, Knight J, Roberts C, 2022,

    Optimal power extraction from active particles with hidden states

    , Publisher: arXiv

    We identify generic protocols achieving optimal power extraction from asingle active particle subject to continuous feedback control under theassumption that the instantaneous velocity, but not the fluctuatingself-propulsion velocity, is accessible to direct observation. Our Bayesianapproach draws on the Onsager-Machlup path integral formalism and isexemplified in the cases of free run-and-tumble and active Ornstein-Uhlenbeckdynamics in one dimension. Such optimal protocols extract positive work even inmodels characterised by time-symmetric positional trajectories and thusvanishing informational entropy production rates. We argue that the theoreticalbounds derived in this work are those against which the performance ofrealistic active matter engines should be compared.

  • Journal article
    Guo Y, Al-Jibury E, Garcia-Millan R, Ntagiantas K, King JWD, Nash AJ, Galjart N, Lenhard B, Rueckert D, Fisher AG, Pruessner G, Merkenschlager Met al., 2022,

    Chromatin jets define the properties of cohesin-driven in vivo loop extrusion

    , Molecular Cell, Vol: 82, Pages: 3769-3780.e5, ISSN: 1097-2765

    Complex genomes show intricate organization in three-dimensional (3D) nuclear space. Current models posit that cohesin extrudes loops to form self-interacting domains delimited by the DNA binding protein CTCF. Here, we describe and quantitatively characterize cohesin-propelled, jet-like chromatin contacts as landmarks of loop extrusion in quiescent mammalian lymphocytes. Experimental observations and polymer simulations indicate that narrow origins of loop extrusion favor jet formation. Unless constrained by CTCF, jets propagate symmetrically for 1-2 Mb, providing an estimate for the range of in vivo loop extrusion. Asymmetric CTCF binding deflects the angle of jet propagation as experimental evidence that cohesin-mediated loop extrusion can switch from bi- to unidirectional and is controlled independently in both directions. These data offer new insights into the physiological behavior of in vivo cohesin-mediated loop extrusion and further our understanding of the principles that underlie genome organization.

  • Journal article
    Roberts C, Pruessner G, 2022,

    Exact solution of a boundary tumbling particle system in one dimension

    , Physical Review Research, ISSN: 2643-1564

    We derive the fully time-dependent solution to a run-and-tumble model for a particle which has tumbling restricted to the boundaries of a one-dimensional interval. This is achieved through a field-theoretic perturbative framework by exploiting an elegant underlying structure of the perturbationtheory. We calculate the particle densities, currents and variance as well as characteristics of the boundary tumbling. The analytical findings, in agreement with Monte-Carlo simulations, show how the particle densities are linked to the scale of diffusive fluctuations at the boundaries. The generality of our approach suggests it could be readily applied to similar problems described by Fokker-Planck equations containing localised reaction terms.

  • Working paper
    Roberts C, Pruessner G, 2022,

    Exact solution of a boundary tumbling particle system in one dimension

    , Publisher: ArXiv

    We derive the fully time-dependent solution to a run-and-tumble model for aparticle which has tumbling restricted to the boundaries of a one-dimensionalinterval. This is achieved through a field-theoretic perturbative framework byexploiting an elegant underlying structure of the perturbation theory. Wecalculate the particle densities, currents and variance as well ascharacteristics of the boundary tumbling. The analytical findings, in agreementwith Monte-Carlo simulations, show how the particle densities are linked to thescale of diffusive fluctuations at the boundaries. The generality of ourapproach suggests it could be readily applied to similar problems described byFokker-Planck equations containing localised reaction terms.

  • Journal article
    Alston H, Cocconi L, Bertrand T, 2022,

    Non-equilibrium thermodynamics of diffusion in fluctuating potentials

  • Journal article
    Cocconi L, Salbreux G, Pruessner G, 2022,

    Scaling of entropy production under coarse graining in active disordered media

    , Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, Vol: 105, ISSN: 1539-3755

    Entropy production plays a fundamental role in the study of non-equilibriumsystems by offering a quantitative handle on the degree of time-reversalsymmetry breaking. It depends crucially on the degree of freedom considered aswell as on the scale of description. It was hitherto unknown how the entropyproduction at one resolution of the degrees of freedom is related to theentropy production at another resolution. This relationship is of particularrelevance to coarse grained and continuum descriptions of a given phenomenon.In this work, we derive the scaling of the entropy production under iterativecoarse graining on the basis of the correlations of the underlying microscopictransition rates. Our approach unveils a natural criterion to distinguishequilibrium-like and genuinely non-equilibrium macroscopic phenomena based onthe sign of the scaling exponent of the entropy production per mesostate.

  • Journal article
    Zhang Z, Pruessner G, 2022,

    Field theory of free Run and Tumble particles in d dimensions

    , Journal of Physics A: Mathematical and Theoretical, Vol: 55, ISSN: 1751-8113

    In this work, Doi–Peliti field theory is used to describe the motion of free run and tumble particles in arbitrary dimensions. After deriving action and propagators, the mean squared displacement and the corresponding entropy production at stationarity are calculated in this framework. We further derive the field theory of free active Brownian particles in two dimensions for comparison.

  • Journal article
    Garcia-Millan R, Pruessner G, 2021,

    Run-and-tumble motion in a harmonic potential: field theory and entropy production

    , Journal of Statistical Mechanics: Theory and Experiment, Vol: 2021, ISSN: 1742-5468

    Run-and-tumble (RnT) motion is an example of active motility where particles move at constant speed and change direction at random times. In this work we study RnT motion with diffusion in a harmonic potential in one dimension via a path integral approach. We derive a Doi-Peliti field theory and use it to calculate the entropy production and other observables in closed form. All our results are exact.

  • Journal article
    Bothe M, Pruessner G, 2021,

    Doi-Peliti field theory of free active ornstein-uhlenbeck particles

    , Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, Vol: 103, Pages: 1-7, ISSN: 1539-3755

    We derive a Doi-Peliti field theory for free active Ornstein-Uhlenbeck particles, or, equivalently, free inertial Brownian particles, and present a way to diagonalize the quadratic part of the action and calculate the propagator. Unlike previous coarse-grained approaches this formulation correctly tracks particle identity and yet can easily be expanded to include potentials and arbitrary reactions.

  • Journal article
    Nesbitt D, Pruessner G, Lee CF, 2021,

    Uncovering novel phase transitions in dense dry polar active fluids using a lattice Boltzmann method

    , New Journal of Physics, Vol: 23, ISSN: 1367-2630

    The dynamics of dry active matter have implications for a diverse collection of biological phenomena spanning a range of length and time scales, such as animal flocking, cell tissue dynamics, and swarming of inserts and bacteria. Uniting these systems are a common set of symmetries and conservation laws, defining dry active fluids as a class of physical system. Many interesting behaviours have been observed at high densities, which remain difficult to simulate due to the computational demand. Here, we show how two-dimensional dry active fluids in a dense regime can be studied using a simple modification of the lattice Boltzmann method. We apply our method on a model that exhibits motility-induced phase separation, and an active model with contact inhibition of locomotion, which has relevance to collective cell migration. For the latter, we uncover multiple novel phase transitions: two first-order and one potentially critical. We further support our simulation results with an analytical treatment of the hydrodynamic equations obtained via the Chapman-Enskog coarse-graining procedure.

  • Journal article
    Amarteifio S, Fallesen T, Pruessner G, Sena Get al., 2021,

    A random-sampling approach to track cell divisions in time-lapse fluorescence microscopy

    , Plant Methods, Vol: 17, ISSN: 1746-4811

    BackgroundParticle-tracking in 3D is an indispensable computational tool to extract critical information on dynamical processes from raw time-lapse imaging. This is particularly true with in vivo time-lapse fluorescence imaging in cell and developmental biology, where complex dynamics are observed at high temporal resolution. Common tracking algorithms used with time-lapse data in fluorescence microscopy typically assume a continuous signal where background, recognisable keypoints and independently moving objects of interest are permanently visible. Under these conditions, simple registration and identity management algorithms can track the objects of interest over time. In contrast, here we consider the case of transient signals and objects whose movements are constrained within a tissue, where standard algorithms fail to provide robust tracking.ResultsTo optimize 3D tracking in these conditions, we propose the merging of registration and tracking tasks into a registration algorithm that uses random sampling to solve the identity management problem. We describe the design and application of such an algorithm, illustrated in the domain of plant biology, and make it available as an open-source software implementation. The algorithm is tested on mitotic events in 4D data-sets obtained with light-sheet fluorescence microscopy on growing Arabidopsis thaliana roots expressing CYCB::GFP. We validate the method by comparing the algorithm performance against both surrogate data and manual tracking.ConclusionThis method fills a gap in existing tracking techniques, following mitotic events in challenging data-sets using transient fluorescent markers in unregistered images.

  • Journal article
    Cocconi L, Kuhn-Regnier A, Neuss M, Sendova-Franks AB, Christensen Ket al., 2021,

    Reconstructing the intrinsic statistical properties of intermittent locomotion through corrections for boundary effects

    , Bulletin of Mathematical Biology, Vol: 83, Pages: 1-17, ISSN: 0092-8240

    Locomotion characteristics are often recorded within bounded spaces, a constraint which introduces geometry-specific biases and potentially complicates the inference of behavioural features from empirical observations. We describe how statistical properties of an uncorrelated random walk, namely the steady-state stopping location probability density and the empirical step probability density, are affected by enclosure in a bounded space. The random walk here is considered as a null model for an organism moving intermittently in such a space, that is, the points represent stopping locations and the step is the displacement between them. Closed-form expressions are derived for motion in one dimension and simple two-dimensional geometries, in addition to an implicit expression for arbitrary (convex) geometries. For the particular choice of no-go boundary conditions, we demonstrate that the empirical step distribution is related to the intrinsic step distribution, i.e. the one we would observe in unbounded space, via a multiplicative transformation dependent solely on the boundary geometry. This conclusion allows in practice for the compensation of boundary effects and the reconstruction of the intrinsic step distribution from empirical observations.

  • Journal article
    Christensen K, Cocconi L, Sendova-Franks AB, 2021,

    Animal intermittent locomotion: a null model for the probability of moving forward in bounded space.

    , Journal of Theoretical Biology, Vol: 510, Pages: 1-19, ISSN: 0022-5193

    We present a null model to be compared with biological data to test for intrinsic persistence in movement between stops during intermittent locomotion in bounded space with different geometries and boundary conditions. We describe spatio-temporal properties of the sequence of stopping points r1,r2,r3,… visited by a Random Walker within a bounded space. The path between stopping points is not considered, only the displacement. Since there are no intrinsic correlations in the displacements between stopping points, there is no intrinsic persistence in the movement between them. Hence, this represents a null-model against which to compare empirical data for directional persistence in the movement between stopping points when there is external bias due to the bounded space. This comparison is a necessary first step in testing hypotheses about the function of the stops that punctuate intermittent locomotion in diverse organisms. We investigate the probability of forward movement, defined as a deviation of less than 90° between two successive displacement vectors, as a function of the ratio between the largest displacement between stops that could be performed by the random walker and the system size, α=Δℓ/Lmax. As expected, the probability of forward movement is 1/2 when α→0. However, when α is finite, this probability is less than 1/2 with a minimum value when α=1. For certain boundary conditions, the minimum value is between 1/3 and 1/4 in 1D while it can be even lower in 2D. The probability of forward movement in 1D is calculated exactly for all values 0<α⩽1 for several boundary conditions. Analytical calculations for the probability of forward movement are performed in 2D for circular and square bounded regions with one boundary condition. Numerical results for all values 0<α⩽1 are presented for several boundary conditions. The cases of rectangle and ellipse are also considered and an approximate model of

  • Journal article
    Walter B, Pruessner G, Salbreux G, 2021,

    First passage time distribution of active thermal particles in potentials

    , Physical Review Research, Vol: 3, Pages: 013075 – 1-013075 – 22, ISSN: 2643-1564

    We introduce a perturbative method to calculate all moments of thefirst-passage time distribution in stochastic one-dimensional processes whichare subject to both white and coloured noise. This class of non-Markovianprocesses is at the centre of the study of thermal active matter, that isself-propelled particles subject to diffusion. The perturbation theory aboutthe Markov process considers the effect of self-propulsion to be small comparedto that of thermal fluctuations. To illustrate our method, we apply it to thecase of active thermal particles (i) in a harmonic trap (ii) on a ring. Forboth we calculate the first-order correction of the moment-generating functionof first-passage times, and thus to all its moments. Our analytical results arecompared to numerics.

  • Journal article
    Cocconi L, de Gennes M, Salbreux G, 2021,

    Strip it out and build it back! Engineering a morphogen gradient

    , TheScienceBreaker, Vol: 07
  • Journal article
    Cocconi L, Garcia Millan R, Zhen Z, Buturca B, Pruessner Get al., 2020,

    Entropy production in exactly solvable systems

    , Entropy: international and interdisciplinary journal of entropy and information studies, Vol: 22, Pages: 1-33, ISSN: 1099-4300

    The rate of entropy production by a stochastic process quantifies how far it is from thermodynamic equilibrium. Equivalently, entropy production captures the degree to which global detailed balance and time-reversal symmetry are broken. Despite abundant references to entropy production in the literature and its many applications in the study of non-equilibrium stochastic particle systems, a comprehensive list of typical examples illustrating the fundamentals of entropy production is lacking. Here, we present a brief, self-contained review of entropy production and calculate it from first principles in a catalogue of exactly solvable setups, encompassing both discrete- and continuous-state Markov processes, as well as single- and multiple-particle systems. The examples covered in this work provide a stepping stone for further studies on entropy production of more complex systems, such as many-particle active matter, as well as a benchmark for the development of alternative mathematical formalisms.

  • Journal article
    Bordeu Weldt I, Garcin C, Habib SJ, Pruessner Get al., 2020,

    Effective potential description of the interaction between single stem cells and localized ligands

    , Physical Review X, Vol: 10, Pages: 041022 – 1-041022 – 18, ISSN: 2160-3308

    Cell signalling is essential for cell fate determination and tissue patterning. As signalling ligandsare presented to the receiving cell, they are recruited and recognised by the cell membrane as to elicita biological response and to pattern multicellular tissues. Cells can accumulate and transport theseligands, which results in an emergent organisation of the ligands' spatial distribution. To study thisorganisation, we make use of a simpli ed experimental setup, in which single mouse embryonic stemcells (mESCs) can interact with immobilized ligands. We introduce a two species age-dependentcorrelation function that allows the description and quanti cation of the spatio-temporal dynamicsof single cell-ligand interactions. Through the analysis of mESC data and numerical simulations weshow that cells act as e ective force- eld generators, perturbing and organising their environment.This organisation, captured in the form of an ageing e ective potential, is an emergent property ofthe population of single cells interacting with randomly distributed localized ligands.

  • Software
    Kuhn-Regnier A, Cocconi L, Neuss M, 2020,


    This is the first release of the software used in our paper investigating bounded random walks.We implemented an adaptive rejection sampling algorithm in both Python and C++, allowing the investigation of bounded random walks given user-specified intrinsic step distributions and convex geometries. Multiple binning techniques are used throughout in order to enable analysis of both 2D gridded and 1D radially-averaged data, and a custom integrator is used to achieve high numerical accuracy where needed.

  • Journal article
    Stapornwongkul KS, de Gennes M, Cocconi L, Salbreux G, Vincent J-Pet al., 2020,

    Patterning and growth control in vivo by an engineered GFP gradient

    , SCIENCE, Vol: 370, Pages: 321-+, ISSN: 0036-8075
  • Journal article
    Pausch J, Garcia-Millan R, Pruessner G, 2020,

    Time‐dependent branching processes: a model of oscillating neuronal avalanches

    , Scientific Reports, Vol: 10, Pages: 1-17, ISSN: 2045-2322

    Recently, neuronal avalanches have been observed to display oscillations, a phenomenon regarded as the co-existenceof a scale-free behaviour (the avalanches close to criticality) and scale-dependent dynamics (the oscillations). Ordinarycontinuous-time branching processes with constant extinction and branching rates are commonly used as models of neuronalactivity, yet they lack any such time-dependence. In the present work, we extend a basic branching process by allowing theextinction rate to oscillate in time as a new model to describe cortical dynamics. By means of a perturbative field theory, wederive relevant observables in closed form. We support our findings by quantitative comparison to numerics and qualitativecomparison to available experimental results.

  • Journal article
    Hiratsuka T, Bordeu I, Pruessner G, Watt FMet al., 2020,

    Regulation of ERK basal and pulsatile activity control proliferation and exit from the stem cell compartment in mammalian epidermis.

    , Proceedings of the National Academy of Sciences of USA, Vol: 117, Pages: 17796-17807, ISSN: 0027-8424

    Fluctuation in signal transduction pathways is frequently observed during mammalian development. However, its role in regulating stem cells has not been explored. Here we tracked spatiotemporal ERK MAPK dynamics in human epidermal stem cells. While stem cells and differentiated cells were distinguished by high and low stable basal ERK activity, respectively, we also found cells with pulsatile ERK activity. Transitions from Basalhi-Pulselo (stem) to Basalhi-Pulsehi, Basalmid-Pulsehi, and Basallo-Pulselo (differentiated) cells occurred in expanding keratinocyte colonies and in response to differentiation stimuli. Pharmacological inhibition of ERK induced differentiation only when cells were in the Basalmid-Pulsehi state. Basal ERK activity and pulses were differentially regulated by DUSP10 and DUSP6, leading us to speculate that DUSP6-mediated ERK pulse down-regulation promotes initiation of differentiation, whereas DUSP10-mediated down-regulation of mean ERK activity promotes and stabilizes postcommitment differentiation. Levels of MAPK1/MAPK3 transcripts correlated with DUSP6 and DUSP10 transcripts in individual cells, suggesting that ERK activity is negatively regulated by transcriptional and posttranslational mechanisms. When cells were cultured on a topography that mimics the epidermal-dermal interface, spatial segregation of mean ERK activity and pulses was observed. In vivo imaging of mouse epidermis revealed a patterned distribution of basal cells with pulsatile ERK activity, and down-regulation was linked to the onset of differentiation. Our findings demonstrate that ERK MAPK signal fluctuations link kinase activity to stem cell dynamics.

  • Journal article
    Gcina M, Luca C, Pruessner G, Moloney Net al., 2020,

    Dynamically accelerated cover times

    , Physical Review Research, Vol: 2, Pages: 023421 – 1-023421 – 9, ISSN: 2643-1564

    Among observables characterizing the random exploration of a graph or lattice, the cover time, namely, the time to visit every site, continues to attract widespread interest. Much insight about cover times is gained by mapping to the (spaceless) coupon collector problem, which amounts to ignoring spatiotemporal correlations, and an early conjecture that the limiting cover time distribution of regular random walks on large lattices converges to the Gumbel distribution in d≥3 was recently proved rigorously. Furthermore, a number of mathematical and numerical studies point to the robustness of the Gumbel universality to modifications of the spatial features of the random search processes (e.g., introducing persistence and/or intermittence, or changing the graph topology). Here we investigate the robustness of the Gumbel universality to dynamical modification of the temporal features of the search, specifically by allowing the random walker to “accelerate” or “decelerate” upon visiting a previously unexplored site. We generalize the mapping mentioned above by relating the statistics of cover times to the roughness of 1/fα Gaussian signals, leading to the conjecture that the Gumbel distribution is but one of a family of cover time distributions, ranging from Gaussian for highly accelerated cover, to exponential for highly decelerated cover. While our conjecture is confirmed by systematic Monte Carlo simulations in dimensions d>3, our results for acceleration in d=3 challenge the current understanding of the role of correlations in the cover time problem.

  • Working paper
    Amarteifio S, Fallesen T, Pruessner G, Sena Get al., 2020,

    A fuzzy-registration approach to track cell divisions in time-lapse fluorescence microscopy

    , Publisher: bioRxiv


  • Journal article
    Bordeu Weldt I, Amarteifio S, Garcia Millan R, Walter B, Wei N, Pruessner Get al., 2019,

    Volume explored by a branching random walk on general graphs

    , Scientific Reports, Vol: 9, ISSN: 2045-2322

    Branching processes are used to model diverse social and physical scenarios, from extinction of family names to nuclear fission. However, for a better description of natural phenomena, such as viral epidemics in cellular tissues, animal populations and social networks, a spatial embedding---the branching random walk (BRW)---is required. Despite its wide range of applications, the properties of the volume explored by the BRW so far remained elusive, with exact results limited to one dimension. Here we present analytical results, supported by numerical simulations, on the scaling of the volume explored by a BRW in the critical regime, the onset of epidemics, in general environments. Our results characterise the spreading dynamics on regular lattices and general graphs, such as fractals, random trees and scale-free networks, revealing the direct relation between the graphs' dimensionality and the rate of propagation of the viral process. Furthermore, we use the BRW to determine the spectral properties of real social and metabolic networks, where we observe that a lack of information of the network structure can lead to differences in the observed behaviour of the spreading process. Our results provide observables of broad interest for the characterisation of real world lattices, tissues, and networks.

  • Journal article
    Wei N, Pruessner G, 2019,

    Critical density of the Abelian Manna model via a multitype branching process

    , Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, Vol: 100, Pages: 1-6, ISSN: 1539-3755

    A multitype branching process is introduced to mimic the evolution of the avalanche activity and determine the critical density of the Abelian Manna model. This branching process incorporates partially the spatiotemporal correlations of the activity, which are essential for the dynamics, in particular in low dimensions. An analytical expression for the critical density in arbitrary dimensions is derived, which significantly improves the results over mean-field theories, as confirmed by comparison to the literature on numerical estimates from simulations. The method can easily be extended to lattices and dynamics other than those studied in the present work.

  • Journal article
    Pausch J, Pruessner G, 2019,

    Is actin filament and microtubule growth reaction- or diffusion-limited?

    , Journal of Statistical Mechanics: Theory and Experiment, Vol: 2019, ISSN: 1742-5468

    Inside cells of living organisms, actin filaments and microtubules selfassemble and dissemble dynamically by incorporating actin or tubulin from the cell plasma or releasing it into their tips’ surroundings. Such reaction-diffusion systems can show diffusion- or reaction-limited behaviour. However, neither limit explains the experimental data: while the offset of the linear relation between growth speed and bulk tubulin density contradicts the diffusion limit, the surprisingly large variance of the growth speed rejects a pure reaction limit. In this article, we accommodate both limits and use a Doi-Peliti field-theory model to estimate how diffusive transport is perturbing the chemical reactions at the filament tip. Furthermore, a crossover bulkdensity is predicted at which the limiting process changes from chemical reactions to diffusive transport. In addition, we explain and estimate larger variances of the growth speed.

  • Journal article
    Duarte D, Amarteifio S, Ang H, Kong IY, Ruivo N, Pruessner G, Hawkins ED, Lo Celso Cet al., 2019,

    Defining the in vivo characteristics of acute myeloid leukemia cells behavior by intravital imaging

    , Immunology and Cell Biology, Vol: 97, Pages: 229-235, ISSN: 0818-9641

    The majority of acute myeloid leukemia (AML) patients have a poor response to conventional chemotherapy. The survival of chemoresistant cells is thought to depend on leukemia-bone marrow (BM) microenvironment interactions, which are not well understood. The CXCL12/CXCR4 axis has been proposed to support AML growth but was not studied at the single AML cell level. We recently showed that T-cell acute lymphoblastic leukemia (T-ALL) cells are highly motile in the BM; however, the characteristics of AML cell migration within the BM remain undefined. Here, we characterize the in vivo migratory behavior of AML cells and their response to chemotherapy and CXCR4 antagonism, using high-resolution 2-photon and confocal intravital microscopy of mouse calvarium BM and the well-established MLL-AF9-driven AML mouse model. We used the Notch1-driven T-ALL model as a benchmark comparison and AMD3100 for CXCR4 antagonism experiments. We show that AML cells are migratory, and in contrast with T-ALL, chemoresistant AML cells become less motile. Moreover, and in contrast with T-ALL, the in vivo exploratory behavior of expanding and chemoresistant AML cells is unaffected by AMD3100. These results expand our understanding of AML cells-BM microenvironment interactions, highlighting unique traits of leukemia of different lineages.

  • Journal article
    Reijne A-M, Bordeu I, Pruessner G, Sena Get al., 2018,

    Linear stability analysis of morphodynamics during tissue regeneration in plants

    , Journal of Physics D: Applied Physics, Vol: 52, Pages: 1-9, ISSN: 0022-3727

    One of the key characteristics of multicellular organisms is the ability to establish and maintain shapes, or morphologies, under a variety of physical and chemical perturbations. A quantitative description of the underlying morphological dynamics is a critical step to fully understand the self-organising properties of multicellular systems. Although many powerful mathematical tools have been developed to analyse stochastic dynamics, rarely these are applied to experimental developmental biology.Here, we take root tip regeneration in the plant model system Arabidopsis thaliana as an example of robust morphogenesis in living tissue, and present a novel approach to quantify and model the relaxation of the system to its unperturbed morphology. By generating and analysing time-lapse series of regenerating root tips captured with confocal microscopy, we are able to extract and model the dynamics of key morphological traits at cellular resolution. We present a linear stability analysis of its Markovian dynamics, with the stationary state representing the intact root in the space of morphological traits. This analysis suggests the intriguing co-existence of two distinct temporal scales during the process of root regeneration in Arabidopsis.We discuss the possible biological implications of our specific results, and suggest future experiments to further probe the self-organising properties of living tissue.

  • Journal article
    Garcia Millan R, Pausch J, Walter B, Pruessner Get al., 2018,

    Field-theoretic approach to the universality of branching processes

    , Physical Review E, Vol: 98, ISSN: 1539-3755

    Branching processes are widely used to model phenomena from networks to neuronal avalanching. In a large class of continuous-time branching processes, we study the temporal scaling of the moments of the instant population size, the survival probability, expected avalanche duration, the so-called avalanche shape, the n-point correlation function, and the probability density function of the total avalanche size. Previous studies have shown universality in certain observables of branching processes using probabilistic arguments; however, a comprehensive description is lacking. We derive the field theory that describes the process and demonstrate how to use it to calculate the relevant observables and their scaling to leading order in time, revealing the universality of the moments of the population size. Our results explain why the first and second moment of the offspring distribution are sufficient to fully characterize the process in the vicinity of criticality, regardless of the underlying offspring distribution. This finding implies that branching processes are universal. We illustrate our analytical results with computer simulations.

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: Request URI: /respub/WEB-INF/jsp/search-t4-html.jsp Query String: id=999&limit=30&resgrpMemberPubs=true&respub-action=search.html Current Millis: 1680029248148 Current Time: Tue Mar 28 19:47:28 BST 2023