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  • Journal article
    Devaux M, Sassi F, 2016,

    Social disparities in hazardous alcohol use: self-report bias may lead to incorrect estimates

    , EUROPEAN JOURNAL OF PUBLIC HEALTH, Vol: 26, Pages: 129-134, ISSN: 1101-1262
  • Journal article
    Sassi F, 2016,

    Taxing sugar

    , BMJ-BRITISH MEDICAL JOURNAL, Vol: 352, ISSN: 0959-535X
  • Book chapter
    Childs PRN, 2016,

    Nanoscale thermometry and temperature measurement

    , RSC Nanoscience and Nanotechnology No. 38, Thermometry at the Nanoscale: Techniques and Selected Applications., Editors: Carlos, Palacio, Publisher: Royal Society of Chemistry, Pages: 3-22, ISBN: 9781849739047

    Temperature measurement on the nanoscale is important for applications such as detecting the local temperature changes associated with microelectronics, optics, microfluidics, chemical reaction and biochemical processes, such as living cells and nanomedicine. The drive for information at this scale comes from the electronics industry, materials development and the biosector, combined with rapid development in enabling technologies such as sensor integration and manufacture. The scale of the application and the nature of physical probes distorting the local temperature field due to thermal conduction effects, or optical probes due to thermal radiation heat transfer or energy associated with excitation of a medium, means that great care needs to be taken in order to provide meaningful measurements. This chapter provides an overview of temperature measurement principles along with a review of some of the principal and emerging technologies for nanoscale temperature measurement.

  • Journal article
    Damiani G, Basso D, Acampora A, Bianchi CBNA, Silvestrini G, Frisicale EM, Sassi F, Ricciardi Wet al., 2015,

    The impact of level of education on adherence to breast and cervical cancer screening: Evidence from a systematic review and meta-analysis

    , PREVENTIVE MEDICINE, Vol: 81, Pages: 281-289, ISSN: 0091-7435
  • Journal article
    Chambers ES, Viardot A, Psichas A, Morrison DJ, Murphy KG, Zac-Varghese SEK, MacDougall K, Preston T, Tedford C, Finlayson GS, Blundell JE, Bell JD, Thomas EL, Mt-Isa S, Ashby D, Gibson GR, Kolida S, Dhillo WS, Bloom SR, Morley W, Clegg S, Frost Get al., 2015,

    Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

    , Gut, Vol: 64, Pages: 1744-1754, ISSN: 0017-5749

    Objective The colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation. We hypothesised that colonic delivery of propionate would increase peptide YY (PYY) and glucagon like peptide-1 (GLP-1) secretion in humans, and reduce energy intake and weight gain in overweight adults.Design To investigate whether propionate promotes PYY and GLP-1 secretion, a primary cultured human colonic cell model was developed. To deliver propionate specifically to the colon, we developed a novel inulin-propionate ester. An acute randomised, controlled cross-over study was used to assess the effects of this inulin-propionate ester on energy intake and plasma PYY and GLP-1 concentrations. The long-term effects of inulin-propionate ester on weight gain were subsequently assessed in a randomised, controlled 24-week study involving 60 overweight adults.Results Propionate significantly stimulated the release of PYY and GLP-1 from human colonic cells. Acute ingestion of 10 g inulin-propionate ester significantly increased postprandial plasma PYY and GLP-1 and reduced energy intake. Over 24 weeks, 10 g/day inulin-propionate ester supplementation significantly reduced weight gain, intra-abdominal adipose tissue distribution, intrahepatocellular lipid content and prevented the deterioration in insulin sensitivity observed in the inulin-control group.Conclusions These data demonstrate for the first time that increasing colonic propionate prevents weight gain in overweight adult humans.

  • Journal article
    Miguel-Aliaga I, 2015,

    Cell scientist to watch - Irene Miguel-Aliaga

    , Journal of Cell Science, Vol: 128, Pages: 3519-3520, ISSN: 1477-9137
  • Journal article
    Reiff T, Jacobson J, Cognigni P, Antonello Z, Ballesta E, Tan KJ, Yew JY, Dominguez M, Miguel-Aliaga Iet al., 2015,

    Endocrine remodelling of the adult intestine sustains reproduction in Drosophila.

    , eLife, Vol: 4, ISSN: 2050-084X

    The production of offspring is energetically costly and relies on incompletely understood mechanisms that generate a positive energy balance. In mothers of many species, changes in key energy-associated internal organs are common yet poorly characterised functionally and mechanistically. In this study, we show that, in adult Drosophila females, the midgut is dramatically remodelled to enhance reproductive output. In contrast to extant models, organ remodelling does not occur in response to increased nutrient intake and/or offspring demands, but rather precedes them. With spatially and temporally directed manipulations, we identify juvenile hormone (JH) as an anticipatory endocrine signal released after mating. Acting through intestinal bHLH-PAS domain proteins Methoprene-tolerant (Met) and Germ cell-expressed (Gce), JH signals directly to intestinal progenitors to yield a larger organ, and adjusts gene expression and sterol regulatory element-binding protein (SREBP) activity in enterocytes to support increased lipid metabolism. Our findings identify a metabolically significant paradigm of adult somatic organ remodelling linking hormonal signals, epithelial plasticity, and reproductive output.

  • Journal article
    Cecchini M, Sassi F, 2015,

    Preventing Obesity in the USA: Impact on Health Service Utilization and Costs

    , PHARMACOECONOMICS, Vol: 33, Pages: 765-776, ISSN: 1170-7690
  • Book
    Franco S, 2015,

    Tackling Harmful Alcohol Use Economics and Public Health Policy Economics and Public Health Policy

    , Publisher: OECD Publishing, ISBN: 9789264181069

    There are, however, new dimensions to the problems engendered by harmful alcohol use throughout the history of humankind (drinking and driving is one example). Although alcohol consumption has declined in many OECD countries in ...

  • Journal article
    Baxter WL, Aurisicchio M, Childs PRN, 2015,

    A psychological ownership approach to designing object attachment

    , Journal of Engineering Design, Vol: 26, Pages: 140-156, ISSN: 0954-4828

    The mental state in which an individual claims an object as theirs is called psychological ownership. Psychological ownership is associated with motives, routes, affordances, and outcomes directly linked to attachment. This research introduces psychological ownership in the context of designing object attachment and identifies affordance principles that help facilitate it. A framework presenting the motives for and routes to psychological ownership is proposed to provide a holistic understanding of object attachment. In the framework each route to psychological ownership, that is, control, intimate knowledge, and self-investment, has a corresponding class of affordances. Overall a total of 16 affordance principles are identified through contextual inquiry with 4 objects (a car, a mobile phone, a pair of shoes, and a park bench). Previous studies have identified various elements of this framework but have fallen short of clearly defining and relating the motives, routes, and affordances to psychological ownership identified here. These affordance principles are readily mapped to experience design models and provide a practical resource for designers. Together, the framework and the affordances inform design decisions and move towards a prescriptive design method for facilitating object attachment.

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