In this section
Browse through all publications from the Institute of Global Health Innovation, which our Patient Safety Research Collaboration is part of. This feed includes reports and research papers from our Centre.
@article{Singh:2025,
author = {Singh, Gill S and Jones, GG and Cobb, J and Alagha, MA},
journal = {Bioengineering},
title = {The link between depression, analgesia usage and function in osteoarthritis: a propensity score-matched analysis from the osteoarthritis initiative cohort},
year = {2025}
}
TY - JOUR
AB - Knee osteoarthritis (OA) affects around 37% of U.S. adults over 60, with over 25% expe-rience depressive symptoms (DSs), linked to worse pain and outcomes. Yet their impact on analgesic use and recovery remains unclear. This study aimed to assess if DSs influ-ence analgesic use and functional outcomes in knee OA. Using data from the Osteoar-thritis Initiative (n = 3680), we used a Machine Learning (ML)- based Gradient Boosting Machine (GBM) model to perform propensity score matching, matching pa-tients with knee OA and DSs (n = 487) to those without DSs (n = 487). Outcomes at baseline, 1 and 2 years included analgesic use, function (WOMAC), quality of life (KOOS-QoL), and physical health (SF-12 PCS). Regression and timepoint models com-pared follow-up with baseline. DSs alone were not associated with greater opioid use up to Year 2 (OR = 0.89, 95% CI: 0.45–1.73; p = 0.73). Among patients with DSs, SF-12 PCS improvement was less likely at Year 1, while decline was more likely up to Year 2. DSs in OA were linked to poorer physical health, but often greater functional gains than those in OA without DSs, and with no difference in opioid use. These findings highlight the need for multidisciplinary strategies, addressing both pain and psychosocial well-being.
AU - Singh,Gill S
AU - Jones,GG
AU - Cobb,J
AU - Alagha,MA
PY - 2025///
SN - 2306-5354
TI - The link between depression, analgesia usage and function in osteoarthritis: a propensity score-matched analysis from the osteoarthritis initiative cohort
T2 - Bioengineering
ER -
