BibTex format
@article{Torquato:2023:10.1039/d3lc00062a,
author = {Torquato, LMG and Hélaine, N and Cui, Y and O'Connell, R and Gummel, J and Robles, ESJ and Jacob, D and Cabral, JT},
doi = {10.1039/d3lc00062a},
journal = {Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering},
pages = {2540--2552},
title = {Microfluidic in-line dynamic light scattering with a commercial fibre optic system.},
url = {http://dx.doi.org/10.1039/d3lc00062a},
volume = {23},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - We report the coupling of dynamic light scattering (DLS) in microfluidics, using a contact-free fibre-optic system, enabling the under-flow characterisation of a range of solutions, dispersions, and structured fluids. The system is evaluated and validated with model systems, specifically micellar and (dilute) polymer solutions, and colloidal dispersions of different radii (∼1-100 nm). A systematic method of flow-DLS analysis is examined as a function of flow velocity (0-16 cm s-1), and considerations of the relative contribution of 'transit' and 'Brownian' terms enable the identification of regions where (i) a quiescent approximation suffices, (ii) the flow-DLS framework holds, as well as (iii) where deviations are found, until eventually (iv) the convection dominates. We investigate practically relevant, robust setups, namely that of a capillary connected to microdevice, as well as direct measurement on a glass microdevice, examining the role of capillary dimensions and challenges of optical alignment. We conclude with a demonstration of a continuous flow measurement of a binary surfactant/salt solution, whose micellar dimensions vary with composition, characterised with hundreds of data points (every ∼5 s) and adequate statistics, within a few minutes.
AU - Torquato,LMG
AU - Hélaine,N
AU - Cui,Y
AU - O'Connell,R
AU - Gummel,J
AU - Robles,ESJ
AU - Jacob,D
AU - Cabral,JT
DO - 10.1039/d3lc00062a
EP - 2552
PY - 2023///
SN - 1473-0189
SP - 2540
TI - Microfluidic in-line dynamic light scattering with a commercial fibre optic system.
T2 - Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering
UR - http://dx.doi.org/10.1039/d3lc00062a
UR - https://www.ncbi.nlm.nih.gov/pubmed/37185587
UR - https://pubs.rsc.org/en/content/articlelanding/2023/LC/D3LC00062A
VL - 23
ER -