In this section
@article{Suresh:2026:10.1007/s00213-026-07170-0,
author = {Suresh, P and Kins, J and Levkovskyy, L and Thieme, A and Wren, P and Ray, T and Barrett, FS and Carhart-Harris, R and Bzdok, D},
doi = {10.1007/s00213-026-07170-0},
journal = {Psychopharmacology (Berl)},
title = {Moving beyond 5-HT2A: language models map neurotransmitter receptors to experiential semantics.},
url = {http://dx.doi.org/10.1007/s00213-026-07170-0},
year = {2026}
}
TY - JOUR
AB - RATIONALE: Psychedelics exhibit rapid, durable therapeutic effects across diverse psychiatric conditions, yet their broad-spectrum psychoactivity poses challenges for clinical translation. OBJECTIVES: As a proof-of-concept, we aimed to quantify associations between 19 neurotransmitter receptors and the subjective effects of 21 psychedelic drugs with broadly assayed binding profiles. METHODS: We used a custom Global Vectors for Word Representation (GloVe)-based semantic embedding model trained on 4,496 firsthand experience reports and integrated it with receptor affinities to identify candidate receptor-linked semantic patterns related to distinct psychoactive effects without imposing predefined categorization systems. RESULTS: While 5-HT2A predictably associates with classic facets of psychedelic experience, our analysis reveals novel associations, including 5-HT1A and 5-HT1B with 'Cognitive Disruption', H1 with 'Interdimensional Communication', and 5-HT7a and 5-HT1E with 'Visual Complexity'.
AU - Suresh,P
AU - Kins,J
AU - Levkovskyy,L
AU - Thieme,A
AU - Wren,P
AU - Ray,T
AU - Barrett,FS
AU - Carhart-Harris,R
AU - Bzdok,D
DO - 10.1007/s00213-026-07170-0
PY - 2026///
TI - Moving beyond 5-HT2A: language models map neurotransmitter receptors to experiential semantics.
T2 - Psychopharmacology (Berl)
UR - http://dx.doi.org/10.1007/s00213-026-07170-0
UR - https://www.ncbi.nlm.nih.gov/pubmed/42809102
ER -
