In this section
@article{Richardson:2026:ijnp/pyag040.152,
author = {Richardson, B and O'Byrne, J and Bruno, V and Comai, S and Carhart-Harris, R and Gobbi, G},
doi = {ijnp/pyag040.152},
journal = {International Journal of Neuropsychopharmacology},
pages = {i82--i83},
title = {410. Comparative neurophysiological signatures of psychedelics, stimulants and anesthetics in rodent cortical activity},
url = {http://dx.doi.org/10.1093/ijnp/pyag040.152},
volume = {29},
year = {2026}
}
TY - JOUR
AB - <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Psychedelics induce altered states of consciousness (AOC) with profound perceptual, cognitive, and emotional shifts, often linked to positive therapeutic outcomes. Although serotonergic psychedelics such as psilocybin, LSD, and 5-MeO-DMT share receptor targets, they differ in behavioral and neural effects. How these compounds alter cortical dynamics relative to other consciousness-modulating agents, including dopaminergic stimulants and anesthetics, remains unclear.</jats:p> </jats:sec> <jats:sec> <jats:title>Aims & Objectives</jats:title> <jats:p>We aimed to delineate the compound-specific neurophysiological signatures of serotonergic psychedelics, dopaminergic stimulants, and anesthetics by examining cortical oscillations, muscular activity, signal complexity, and spectral entropy.</jats:p> </jats:sec> <jats:sec> <jats:title>Method</jats:title> <jats:p>Rodents received i.p. injections of psilocybin (6 mg/kg), LSD (0.2 mg/kg), 5-MeO-DMT (10 mg/kg), lisuride (0.5 mg/kg), d-amphetamine (5 mg/kg), or propofol (100 mg/kg). Electrocorticography (ECoG) and electromyography (EMG) recorded cortical and muscular activity. Analyses included absolute and relative power across canonical delta (0.5-4 Hz), theta (4-8 Hz), alpha (8-13Hz), beta (13-30Hz), and gamma (30-40 Hz) bands, Lempel-Ziv complexity (LZ) and Higuchi fractal dimension (HFD) to assess signal diversity, and spectral entropy to quantify frequency-specific unpredictability. Principal component and clustering analyses identified compound-specific patterns.</jats:p> </jats:sec>
AU - Richardson,B
AU - O'Byrne,J
AU - Bruno,V
AU - Comai,S
AU - Carhart-Harris,R
AU - Gobbi,G
DO - ijnp/pyag040.152
EP - 83
PY - 2026///
SN - 1461-1457
SP - 82
TI - 410. Comparative neurophysiological signatures of psychedelics, stimulants and anesthetics in rodent cortical activity
T2 - International Journal of Neuropsychopharmacology
UR - http://dx.doi.org/10.1093/ijnp/pyag040.152
UR - https://doi.org/10.1093/ijnp/pyag040.152
VL - 29
ER -
