Course Information

Date of next cohort: 1st May - 19th June 2026 

Application deadline: 30th March (Applications open 20th February) 

Cost: £̶5̶0̶0̶...£0 (due to course being piloted)

Duration: 8 weeks 

Time commitment: 8 x 3 hour sessions (one half-day per week)  

Location: South Kensington Campus and White City Campus, Imperial College London 

Format: Each week typically includes a 90-minute lecture, a 60-90 minute seminar and opportunities for networking with Imperial researchers and fellow participants. 

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About the programme

Following the success of the Imperial Policy Forum’s courses on artificial intelligence and quantum technologies, we are piloting a new course on engineering biology.  

Engineering biology underpins technologies such as sustainable proteins, synthetic vaccines, engineered cells and microbes, and new biomanufacturing platforms. These capabilities are increasingly central to priorities such as health resilience, biosecurity, food security, economic growth and the net zero transition. 

Drawing on Imperial’s world leading expertise across engineering, life sciences and medicine, the programme combines: 

  • accessible lectures from leading researchers 
  • seminars focused on public policy implications 
  • case studies on real-world deployments 

By the end of the course, participants will be able to act as informed “expert customers” when commissioning analysis, designing interventions or scrutinising the use of engineering biology in public services and wider society. 

Who is this course for?

The Engineering Biology Fundamentals programme is designed for UK civil servants and public sector professionals of any grade who are: 

  • working on, or adjacent to, life sciences, health, food, environment, science and technology, or economic policy 
  • involved in research, innovation, regulation, industrial strategy, resilience, or national security (including arms-length bodies, regulators, and parliamentary staff) 
  • seeking to build confidence engaging with engineers, scientists and industry on engineering biology  

Participants do not need technical training in biology or engineering. The course is suitable for: 

  • policy generalists and scientific officers/advisers who need to understand the fundamentals 
  • analysts and economists seeking to ground their work in realistic technical assumptions 
  • strategists working on long term plans for growth, resilience and technology adoption 

Programme outline

Week 1: Foundations of Engineering Biology
  • Fundamental concepts and terminology in engineering biology and synthetic biology 
  • Comparing traditional biotechnology with engineering biology (standardisation, modularity, design–build–test–learn cycles) 
  • Key enabling tools and platforms (e.g. DNA synthesis, CRISPR, biofoundries) 
Week 2: Advanced Fundamentals - Data, Design and Complexity
  • Bioinformatics, genome scaling and metabolic models 
  • Design principles for genetic circuits, metabolic pathways and chassis organisms 
  • Examining the boundary between engineering ability and biological complexity 
  • Opportunities and limitations of automation, high-throughput experimentation and AI-assisted design 
Week 3: Cellular Engineering, Synthetic Genomes and Synthetic Cells
  • Cellular engineering: reprogramming microbes, mammalian and plant cells 
  • Synthetic genomes, minimal cells and protocells: what has been achieved and what remains speculative 
  • Potential societal impacts of cellular engineering and synthetic genomes in the UK 
Week 4: Applications of Engineering Biology in Health, Security and Industry
  • Platform technologies for rapid vaccine and therapeutic development 
  • Engineering biology and biosecurity: threat reduction, detection and response 
  • Economic impacts of these technologies in the UK pharmaceutical and life science sectors 
Week 5: Sustainable Proteins, Food Systems and Biofoundries
  • Engineering microbes, plants and cell-based systems for alternative proteins, flavours and functional ingredients 
  • Site visits to Imperial’s Food Labs and Biofoundry 
Week 6: Growth, Economic Security and Scaling of Engineering Biology
  • Industrialisation pathways: from lab-scale proofs of concept to pilot plants and full-scale manufacturing 
  • Growth, economic security and scaling of engineering biology 
  • Presentations from several engineering biology startups 
Week 7: Policy, Strategy and Communication of Engineering Biology
  • International engagement, regulation, risk and responsible research and innovation (RRI) 
  • Risk governance: biosafety, biosecurity and societal concerns 
  • Public engagement, narratives and media: how engineering biology is understood and contested globally 
Week 8: The Future of Engineering Biology and UK Capability
  • The future of engineering biology in the context of converging technologies 
  • AI for Science Strategy focus areas: people/culture, data, and compute 
  • International standards, collaboration and competition 

Impact

What do Fundamentals graduates have to say about our courses? 

‘The integration of diverse topics, perspectives, and content—combined with thoughtful discussion and research-based insights—made it a truly exceptional experience. I found it both highly enjoyable and extremely informative.’ Senior Civil Servant, AI Safety Institute
'As a non-technical professional, I left the course feeling more informed and confident about how models are developed, the key technical considerations, and how I can translate this knowledge into comprehensive policy advice.’ Senior Civil Servant, Department for Science, Innovation, and Technology

Benefits

Participants will: 

  • Build a foundation of knowledge in the key concepts and terminology of engineering biology. 
  • Understand cutting-edge tools and methods such as bioinformatics, genome engineering, cell engineering and biofoundries, and how they translate into practical capabilities. 
  • Explore real-world applications across health, pharmaceuticals, sustainable food, biosecurity, climate and industrial biotechnology. 
  • Gain insight into commercialisation pathways, including startups, scaleups and biomanufacturing infrastructure in the UK and internationally. 
  • Develop policy relevant frameworks for assessing opportunities, risks, governance and regulation, including responsible research and innovation and dual-use concerns. 
  • Engage directly with experts through seminars, Q&A sessions and site visits, building networks across government, academia and industry. 
  • Increase confidence in commissioning research, assessing evidence and contributing to strategies on engineering biology, from national initiatives to department level programmes. 

Faculty

  • Professor Karen Polizzi

    Personal details

    Professor Karen Polizzi Programme Lead

    Biography

    Professor Polizzi is a leading figure in synthetic biology and bioprocessing at Imperial College London. Karen leads an interdisciplinary team of scientists and engineers working broadly in the application of synthetic biology to biological manufacturing.    

    Beyond her research, Professor Polizzi plays an active role in shaping the future of biotechnology through her teaching, mentorship, and leadership. She collaborates widely with industry and academia and is passionate about training the next generation of synthetic biologists. Professor Polizzi is also a committed advocate for diversity and inclusion in STEM and serves on multiple advisory boards promoting equality in science and engineering.    

  • Professor Geoff Baldwin

    Personal details

    Professor Geoff Baldwin

    Biography

    Professor Baldwin is Co-Director of the Imperial College Centre for Synthetic Biology and Director of the EPSRC Centre for Doctoral Training in BioDesign Engineering. His career has been characterised by a focus on the intersection of the physical and life sciences, as well as engineering within the realm of synthetic biology. His recent research interests include enhancing data-led approaches through the integration of artificial intelligence (AI).  

  • Professor Rodrigo Ledesma-Amaro

    Personal details

    Professor Rodrigo Ledesma-Amaro

    Biography

    Professor Ledesma-Amaro is Director of the Bezos Centre for Sustainable Protein at Imperial College London, where he leads a research group working on Engineering Biology and sustainability. His research focuses on the use of microorganisms to convert renewable feedstocks into valuable products (such as food ingredients). He has published over 150 articles, most on topics related to microbial bioproduction (precision, biomass and traditional fermentation). He is the director of the Bezos Centre for Sustainable Protein and the UKRI Microbial Food Hub.