BibTex format
@article{Tan:2023:10.1038/s41467-023-38717-w,
author = {Tan, C and Trew, J and Peacock, T and Mok, KY and Hart, C and Lau, K and Ni, D and Orme, CDL and Ransome, E and Pearse, W and Coleman, C and Bailey, D and Thakur, N and Quantrill, J and Sukhova, K and Richard, D and Kahane, L and Woodward, G and Bell, T and Worledge, L and Nunez-Mino, J and Barclay, W and van, Dorp L and Balloux, F and Savolainen, V},
doi = {10.1038/s41467-023-38717-w},
journal = {Nature Communications},
pages = {1--13},
title = {Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential},
url = {http://dx.doi.org/10.1038/s41467-023-38717-w},
volume = {14},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - There has been limited characterisation of bat-borne coronaviruses in Europe. Here, we screened for coronaviruses in 48 faecal samples from 16 of the 17 bat species breeding in the UK, collected through a bat rehabilitation and conservationist network. We recovered nine (two novel) complete genomes across six bat species: four alphacoronaviruses, a MERS-related betacoronavirus, and four closely related sarbecoviruses. We demonstrate that at least one of these sarbecoviruses can bind and use the human ACE2 receptor for infecting human cells, albeit suboptimally. Additionally, the spike proteins of these sarbecoviruses possess an R-A-K-Q motif, which lies only one nucleotide mutation away from a furin cleavage site (FCS) that enhances infectivity in other coronaviruses, including SARS-CoV-2. However, mutating this motif to an FCS does not enable spike cleavage. Overall, while UK sarbecoviruses would require further molecular adaptations to infect humans, their zoonotic risk is unknown and warrants closer surveillance.
AU - Tan,C
AU - Trew,J
AU - Peacock,T
AU - Mok,KY
AU - Hart,C
AU - Lau,K
AU - Ni,D
AU - Orme,CDL
AU - Ransome,E
AU - Pearse,W
AU - Coleman,C
AU - Bailey,D
AU - Thakur,N
AU - Quantrill,J
AU - Sukhova,K
AU - Richard,D
AU - Kahane,L
AU - Woodward,G
AU - Bell,T
AU - Worledge,L
AU - Nunez-Mino,J
AU - Barclay,W
AU - van,Dorp L
AU - Balloux,F
AU - Savolainen,V
DO - 10.1038/s41467-023-38717-w
EP - 13
PY - 2023///
SN - 2041-1723
SP - 1
TI - Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-023-38717-w
UR - https://www.nature.com/articles/s41467-023-38717-w
UR - http://hdl.handle.net/10044/1/104444
VL - 14
ER -