In this section
@article{Bodero:2016:10.1055/s-0036-1588348,
author = {Bodero, O and Spivey, AC},
doi = {10.1055/s-0036-1588348},
journal = {Synlett},
title = {An expedient synthesis of 2-aryl-1,4-benzoxazin-3-ones via tandem Anionic cyclisation/alkylation reactions of N-Boc-O-benzyl-2-aminophenols},
url = {http://dx.doi.org/10.1055/s-0036-1588348},
volume = {27},
year = {2016}
}
TY - JOUR
AB - A one-pot, tandem anionic cyclization/alkylation reaction of N-Boc-O-benzylated-2-aminophenols to give 2-aryl-1,4-benzoxazin-3-ones is described. The Boc protecting group plays a crucial role in the process, as the tert-butoxide liberated in the cyclisation step facilitates the benzylic deprotonation necessary for the subsequent alkylation. The reaction gives expedient access to a range of substitution patterns in 1,4-benzoxazin-3-ones of potential biological relevance.
AU - Bodero,O
AU - Spivey,AC
DO - 10.1055/s-0036-1588348
PY - 2016///
SN - 0936-5214
TI - An expedient synthesis of 2-aryl-1,4-benzoxazin-3-ones via tandem Anionic cyclisation/alkylation reactions of N-Boc-O-benzyl-2-aminophenols
T2 - Synlett
UR - http://dx.doi.org/10.1055/s-0036-1588348
UR - http://hdl.handle.net/10044/1/43004
VL - 27
ER -
Email: a.c.spivey@imperial.ac.uk
Skype: alan.spivey
Tel & Fax: +44 (0)20 75945841
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