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• Journal article
  Khawaja AA, Whitlock G, Fidler S, Soler-Carracedo A, Henderson M, Taylor GP, Boffito M, Emerson Met al., 2025,

  Evaluation of the effect of 48 weeks of BIC/F/TAF and DRV/c/F/TAF on platelet function in the context of rapid ART start

  , HIV RESEARCH & CLINICAL PRACTICE, Vol: 26, ISSN: 2578-7489
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• Journal article
  Cooke GS, Walker SA, Barnes E, Thwaites G, Van Vinh Chau Net al., 2025,

  HCV response-guided therapy: is shorter always better? - Authors' reply.

  , Lancet, Vol: 406
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• Journal article
  Rotsaert A, Phiri M, Sigande L, Schaap A, Zulu-Phiri R, Simuyaba M, Mwape L, Floyd S, Fidler S, Hayes R, Simwinga M, Ayles H, Hensen Bet al., 2025,

  Unmet need for contraceptives and unintended pregnancies among adolescent girls and young women aged 15 to 24 in Zambia: insights from the Yathu Yathu trial.

  , Reprod Health, Vol: 22

  BACKGROUND: In Sub-Saharan Africa, unmet need for contraceptives often remains high among adolescent girls and young women (AGYW), leading to unintended pregnancies. Yathu Yathu, a cluster-randomised trial of a community-based intervention conducted in two communities in Lusaka, Zambia (2019-2021), aimed to provide sexual and reproductive health services, including contraceptive services, to adolescents and young people. The trial showed no impact on pregnancy related outcomes. Hence, this analysis examined the characteristics of AGYW aged 15-24 with an unmet need for modern contraceptives and who experienced an unintended pregnancy. We also explored access to and reach of contraceptive services through Yathu Yathu. METHODS: Secondary analysis of Yathu Yathu endline survey data. Using logistic regression, adjusted for cluster, we explored factors associated with unmet need for modern contraceptives and unintended pregnancies among AGYW in the intervention arm and assessed whether these associations differed in the control arm. Using routinely collected service delivery data from the intervention arm, numbers of AGYW accessing hormonal contraceptive services were described by age, community, educational attainment, and marital status. RESULTS: In the intervention arm, 395 AGYW ever had sex. Unmet need for modern contraceptives was 40.6% (101/249) among AGYW who had sex in the last 12 months and wished to prevent or space childbearing. Unmet need was higher among younger and single/never married AGYW; in control zones unmet need was additionally higher among those currently in school or with infrequent discussion about sexual health promotion with their sexual partners. Among AGYW ever having had sex, 42.1% (165/392) reported an unintended pregnancy. This was higher among AGYW aged 20-24 years and currently not in school, and additionally among those in control zones who reported food absence. According to the routinely collected data, 12.3% (859/7005) of AGYW in inte

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• Journal article
  Fumagalli MJ, Kaczynska A, Allombert M, Lopes-Ribeiro Á, de Oliveira Silva M, Hernandez BJ, Lavine C, Espinosa SM, Brown H, Box H, Falaschetti E, Cherrill L-R, Elliott T, Lee M, Fox J, Pett S, Clarke A, Uriel A, Sogaard O, Sutherland R, Boffito M, Kinloch-Loes S, Orkin C, Collins S, Zacharopoulou P, Robison N, Bittar C, Oliveira T, Gazumyan A, Jankovic M, Seaman MS, Frater J, Caskey M, Fidler S, Nussenzweig MCet al., 2025,

  Enhanced HIV-1 Control After Antibody Therapy is Associated with Autologous Antibodies and Reservoir Clearance in the RIO trial.

  , medRxiv

  RIO is an ongoing double blind randomized placebo controlled human trial in which participants that started antiretroviral therapy (ART) during primary or early-stage infection underwent treatment interruption and were randomly assigned to a group receiving one or two doses of two long acting broadly neutralizing antibodies 3BNC117-LS and 10-1074-LS (Arm A), or saline (Arm B). The two arms differed significantly in time to viral rebound, ART restart and number of individuals that remained off therapy after 96 weeks (p=0.001) 1 . Here we report on the relationship between viremic control, the latent HIV-1 proviral reservoir, rebound viruses and their sensitivity to the infused and autologous antibodies. Pre-infusion reservoir measurements showed low levels of intact proviral HIV-1 DNA in circulating CD4+ T cells in both arms. The rebounding viruses in participants that received the antibodies, showed significant selection for resistance to 10-1074-LS but not to 3BNC117-LS. Notably, there was a significant correlation between initial reservoir sensitivity to autologous antibodies and to 10-1074 and time to rebound. Finally, comparison of pre-infusion and pre-rebound HIV-1 proviral reservoir in participants that received antibodies showed that the reservoir of intact proviruses decayed faster than earlier reports with a half-life of 0.65 years.

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• Journal article
  Jones EM, Sourij C, Stradner M, Schlenke P, Sereban N, Moser O, Quinlan R, Short C-E, Harris BHL, Fertleman M, Taylor GP, Oliver N, Sourij H, Dominguez-Villar Met al., 2025,

  IL-10- and IL-13-biased T cell responses to SARS-CoV-2 vaccination in diabetes

  , European Journal of Immunology, ISSN: 0014-2980

  Type 1 and type 2 diabetes are associated with increased severity and mortality from respiratory virus infections. Vaccination in the general population significantly reduces the risk of severe respiratory viral infection and triggers a strong, polyfunctional and lasting T cell response in healthy individuals. However, vaccine effectiveness in people with type 1 diabetes is unclear. Here we studied the magnitude and functional characteristics of vaccine-specific CD4+ and CD8+ T cell responses to vaccination in people with type 1 and type 2 diabetes and compared them to those of people living without diabetes, using severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine as a model. We found defects in both CD4+ and CD8+ T cell memory maintenance and the functionality of the vaccine-specific T cells in people with diabetes compared to people without. In those individuals with type 1 and type 2 diabetes that harbored detectable vaccine-specific T cells, they displayed an unfocused, tolerogenic phenotype characterized by increased expression of IL-10 and IL-13 compared to people without diabetes. These results have implications for vaccination strategies for people with diabetes.

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• Journal article
  Taylor GP, Loikith PC, Lee HK, Rahimi S, Hall Aet al., 2025,

  Historical and Future Autumn Rain and Wind Onset Over Western North America Using Regional Climate Models

  , JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, Vol: 130, ISSN: 2169-897X
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• Journal article
  Henderson M, Klastrup V, Ahmad S, Glenn J, Ayres S, Jadayel H, Seery P, Foster C, Fidler Set al., 2025,

  Evaluation of Cardiovascular Risk Factors Among Adults With Perinatally Acquired HIV

  , OPEN FORUM INFECTIOUS DISEASES, Vol: 12, ISSN: 2328-8957
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• Journal article
  Bradshaw D, Taylor GP, 2025,

  Human T-cell lymphotropic virus type 1

  , SEXUALLY TRANSMITTED INFECTIONS, Vol: 101, Pages: 495-496, ISSN: 1368-4973
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• Journal article
  Campbell C, Wang T, Stockdale AJ, Todd S, Jaworski J, Glampson B, Papadimitriou D, Mayer E, Salih H, Roadknight G, Little S, Noble T, Varnai KA, Davis C, Heinson AI, George M, Borca F, Roberts T, Ribeyre BB, English L, Zhu L, NIHR HICVHLDC, Woods K, Davies J, Cooke GS, Nastouli E, Khakoo SI, Gelson W, Elsharkawy AM, Barnes E, Matthews PCet al., 2025,

  Hepatitis B Virus (HBV) Treatment Eligibility in the UK: Retrospective Longitudinal Cohort Data to Explore the Impact of Changes in Clinical Guidelines

  , JOURNAL OF VIRAL HEPATITIS, Vol: 32, ISSN: 1352-0504
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• Journal article
  Guzman V, Di Gravio C, Cooper E, Lound A, Smith N, O'hara M, Atchison CJ, Cooke G, Chadeau M, Elliott P, Ward Het al., 2025,

  "I Put a Lot of Emphasis on Work Because I Want to Keep My Job": A Population-Based Interview Study of Long Covid and Employment Changes in England

  , HEALTH EXPECTATIONS, Vol: 28, ISSN: 1369-6513
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