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@article{Cassar:2020:10.1080/22221751.2020.1752117,
author = {Cassar, O and Desrames, A and Marçais, A and Gout, O and Taylor, GP and Hermine, O and Soriano, V and Mendoza, CD and Dehan, O and Mener, ML and Afonso, PV and Gessain, A},
doi = {10.1080/22221751.2020.1752117},
journal = {Emerging Microbes and Infections},
pages = {913--923},
title = {Multiple recombinant events in human T-Cell leukemia virus type 1: complete sequences of recombinant African strains.},
url = {http://dx.doi.org/10.1080/22221751.2020.1752117},
volume = {9},
year = {2020}
}
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TY  - JOUR
AB  - Africa is the largest known endemic area for HTLV-1, with a high diversity of molecular genotypes. We previously demonstrated that some HTLV-1 strains from North Africa (the a-NA clade) are the result of a recombinant event between Senegalese and West African strains. To better characterize these recombinants and their distribution, we sequenced the LTR region and/or a env gene fragment of a series of 52 HTLV-1 strains from 13 different countries in North and West Africa. Four samples from descendants of African slaves and native to French Guiana were also added. Furthermore, we characterized the complete sequence for 7 viral strains, from the different genotypes. Until now, no complete sequence was available for a-NA clade. Phylogenetic analysis demonstrates that most of the new African strains belong to the Cosmopolitan a-genotype. Ten new strains from the recombinant North African (a-NA) clade could be found in Morocco, Western Sahara, Mali, Guinea, Côte d'Ivoire, and Ghana. We also identified a new clade (named a-G-Rec) comprising 4 strains from Guinea and Ghana that arose from a distinct recombination event between strains from Senegal and West Africa. The analyses of complete sequences suggest that recombination does not only occur in the LTR but also in other regions (env/pol) of the genome. Our data strongly suggest that a-NA and a-G-Rec strains have a mosaic profile with genetic segments deriving from either a-WA or a-Sen strains. In conclusion, our work demonstrates that recombination in HTLV-1 may not be such a rare event as previously proposed.
AU  - Cassar,O
AU  - Desrames,A
AU  - Marçais,A
AU  - Gout,O
AU  - Taylor,GP
AU  - Hermine,O
AU  - Soriano,V
AU  - Mendoza,CD
AU  - Dehan,O
AU  - Mener,ML
AU  - Afonso,PV
AU  - Gessain,A
DO  - 10.1080/22221751.2020.1752117
EP  - 923
PY  - 2020///
SN  - 2222-1751
SP  - 913
TI  - Multiple recombinant events in human T-Cell leukemia virus type 1: complete sequences of recombinant African strains.
T2  - Emerging Microbes and Infections
UR  - http://dx.doi.org/10.1080/22221751.2020.1752117
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32249692
UR  - https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1752117
VL  - 9
ER  -
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