Citation

BibTex format

@article{Smith:2023:10.12688/wellcomeopenres.19012.1,
author = {Smith, C and Smith, E and Chiu, C and Hinton, J and Perez, Sepulveda B and Gordon, M and Choy, RKM and Hill, PWS and Meiring, JE and Darton, TC and Carey, ME and Cooke, G and Gibani, MM},
doi = {10.12688/wellcomeopenres.19012.1},
journal = {Wellcome Open Research},
pages = {111--111},
title = {The Challenge Non-Typhoidal Salmonella (CHANTS) Consortium: Development of a non-typhoidal Salmonella controlled human infection model: Report from a consultation group workshop, 05 July 2022, London, UK},
url = {http://dx.doi.org/10.12688/wellcomeopenres.19012.1},
volume = {8},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <ns4:p>Invasive non-typhoidal <ns4:italic>Salmonella</ns4:italic> disease (iNTS) is a major cause of morbidity and mortality globally, particularly as a cause of bloodstream infection in children and immunocompromised adults in sub-Saharan Africa. Vaccines to prevent non-typhoidal<ns4:italic> Salmonella</ns4:italic> (NTS) would represent a valuable public health tool in this setting to avert cases and prevent expansion of antimicrobial resistance. Several NTS and combination typhoidal-NTS vaccine candidates are in early-stage development, although the pathway to licensure is unclear due to challenges in conducting large phase III field trials.</ns4:p><ns4:p> </ns4:p><ns4:p> Controlled human infection models (CHIM) present an opportunity to accelerate vaccine development for a range of enteric pathogens. Several recent typhoidal <ns4:italic>Salmonella</ns4:italic> CHIMs have been conducted safely and have played pivotal roles in progressing vaccine candidates to pre-qualification and licensure. The Challenge Non-Typhoidal <ns4:italic>Salmonella</ns4:italic> (CHANTS) consortium has been formed with funding from the Wellcome Trust, to deliver the first NTS CHIM, which can act as a platform for future vaccine evaluation.</ns4:p><ns4:p> </ns4:p><ns4:p> This paper reports the conclusions of a consultation group workshop convened with key stakeholders. The aims of this meeting were to: (1) define the rationale for an NTS CHIM (2) map the NTS vaccine pipeline (3) refine study design and (4) establish potential future use cases.</ns4:p>
AU  - Smith,C
AU  - Smith,E
AU  - Chiu,C
AU  - Hinton,J
AU  - Perez,Sepulveda B
AU  - Gordon,M
AU  - Choy,RKM
AU  - Hill,PWS
AU  - Meiring,JE
AU  - Darton,TC
AU  - Carey,ME
AU  - Cooke,G
AU  - Gibani,MM
DO  - 10.12688/wellcomeopenres.19012.1
EP  - 111
PY  - 2023///
SP  - 111
TI  - The Challenge Non-Typhoidal Salmonella (CHANTS) Consortium: Development of a non-typhoidal Salmonella controlled human infection model: Report from a consultation group workshop, 05 July 2022, London, UK
T2  - Wellcome Open Research
UR  - http://dx.doi.org/10.12688/wellcomeopenres.19012.1
UR  - https://doi.org/10.12688/wellcomeopenres.19012.1
VL  - 8
ER  -
Download