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BibTex format

@article{Henderson:2025:10.1111/hiv.70001,
author = {Henderson, M and Lyons, D and Beddows, S and Cowen, M and Panwar, K and Wright, C and Ujetz, J and Crook, E and Patel, H and Smith, D and Foster, C and Fidler, S and Elliott, T},
doi = {10.1111/hiv.70001},
journal = {HIV Medicine},
pages = {709--720},
title = {Highrisk human papillomavirus prevalence and serostatus in a cohort of cisgender women and people with a cervix living with perinatally acquired HIV},
url = {http://dx.doi.org/10.1111/hiv.70001},
volume = {26},
year = {2025}
}
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TY  - JOUR
AB  - ObjectivesHuman papillomavirus (HPV)-associated cervical cancer risk is greater in people with HIV, although this has been at least partially attenuated by antiretroviral medication, enhanced cervical screening and HPV vaccination. People with perinatally acquired HIV may remain at higher risk due to lifelong immunosuppression and potentially reduced vaccine effectiveness. In this study in people with a cervix with perinatally acquired HIV, we explored cervical high-risk HPV (hrHPV) prevalence and HPV serostatus.MethodsParticipants were recruited from a London HIV service between 2020 and 2022. Cervical samples from those sexually active were analysed for hrHPV (Cepheid GeneXpert) and cytology, and, if abnormal, a referral was made to colposcopy. Serum samples were tested for antibodies against HPV6/11/16/18/31/33/45/52/58. A self-reported questionnaire including HPV vaccination history was completed.ResultsFifty-seven people were recruited with a median age of 25 years (range 18–34). Of those providing a cervical sample, 15/47 (32%) were hrHPV-positive and 12/40 (30%) had abnormal cytology; 1/17 referred for colposcopy had CIN2 (6%); 7/15 (47%) with hrHPV were below the national screening age of 24.5 years (range 19–23), and 9/15 (60%) reported previous HPV vaccination. No vaccinated participants had hrHPV16/18. Of those vaccinated, 37/39 (95%) were seropositive for HPV16 and 30/39 (77%) for HPV18. Two vaccinated participants were seronegative for HPV16/18; both had detectable HIV viral loads and CD4 counts <200 cells/μL at recruitment.ConclusionIn this small observational study we identified a 32% prevalence of cervical hrHPV. Cervical screening and HPV vaccination remain vital in this group, with further data required to inform screening guidelines for this population.
AU  - Henderson,M
AU  - Lyons,D
AU  - Beddows,S
AU  - Cowen,M
AU  - Panwar,K
AU  - Wright,C
AU  - Ujetz,J
AU  - Crook,E
AU  - Patel,H
AU  - Smith,D
AU  - Foster,C
AU  - Fidler,S
AU  - Elliott,T
DO  - 10.1111/hiv.70001
EP  - 720
PY  - 2025///
SN  - 1464-2662
SP  - 709
TI  - Highrisk human papillomavirus prevalence and serostatus in a cohort of cisgender women and people with a cervix living with perinatally acquired HIV
T2  - HIV Medicine
UR  - http://dx.doi.org/10.1111/hiv.70001
UR  - https://doi.org/10.1111/hiv.70001
VL  - 26
ER  -
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