In this section
@article{Simmons:2015:cid/civ396,
author = {Simmons, B and Saleem, J and Heath, K and Cooke, GS and Hill, AM},
doi = {cid/civ396},
journal = {Clinical Infectious Diseases},
pages = {730--740},
title = {Long-term treatment outcomes of patients infected with Hepatitis C virus: a systematic review and meta-analysis of the survival benefit of achieving a Sustained Virological Response},
url = {http://dx.doi.org/10.1093/cid/civ396},
volume = {61},
year = {2015}
}
TY - JOUR
AB - Background. Achievement of a sustained virologic response (SVR) after treatment for Hepatitis C infection is associated with improved outcomes. This meta-analysis aimed to determine the impact of SVR on long-term mortality risk compared with non-responders in a range of populations.Methods. An electronic search identified all studies assessing all-cause mortality in SVR and non-SVR patients. Eligible articles were stratified into general, cirrhotic, and HIV co-infected populations. The adjusted hazard ratio (95%CI) for mortality in patients achieving SVR versus non-SVR, and pooled estimates for the five-year mortality in each group were calculated.Results. 31 studies (n=33,360) were identified as suitable for inclusion. Median follow-up time was 5.4 years (IQR 4.9-7.5) across all studies. The adjusted hazard ratio of mortality for patients achieving SVR versus non-SVR was 0.50 (95%CI 0.37-0.67) in the general population, 0.26 (95%CI 0.18-0.74) in the cirrhotic group, and 0.21 (0.10-0.45) in the co-infected group. The pooled five-year mortality rates were significantly lower for patients achieving SVR compared with non-SVR in all three populations.Conclusions. The results suggest that there is a significant survival benefit of achieving an SVR compared with unsuccessful treatment in a range of HCV-infected populations.
AU - Simmons,B
AU - Saleem,J
AU - Heath,K
AU - Cooke,GS
AU - Hill,AM
DO - cid/civ396
EP - 740
PY - 2015///
SN - 1537-6591
SP - 730
TI - Long-term treatment outcomes of patients infected with Hepatitis C virus: a systematic review and meta-analysis of the survival benefit of achieving a Sustained Virological Response
T2 - Clinical Infectious Diseases
UR - http://dx.doi.org/10.1093/cid/civ396
UR - https://academic.oup.com/cid/article/61/5/730/304546
VL - 61
ER -