BibTex format
@article{Ansari:2017:10.1038/ng.3835,
author = {Ansari, A and Pedergnana, V and Ip, C and Magri, A and von, Delft A and Bonsall, D and Chaturvedi, N and Bartha, I and Smith, D and Nicholson, D and McVean, G and Trebes, A and Piazza, P and Fellay, J and Cooke, GS and Foster, G and STOPHCV, consortium and Hudson, E and McLauchlan, J and Simmonds, P and Bowden, R and Klenerman, P and Barnes, E and Spencer, C},
doi = {10.1038/ng.3835},
journal = {Nature Genetics},
pages = {666--673},
title = {Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus},
url = {http://dx.doi.org/10.1038/ng.3835},
volume = {49},
year = {2017}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. We use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 542 individuals chronically infected with HCV, predominately genotype 3. We show that both HLA alleles and interferon lambda innate immune system genes drive viral genome polymorphism, and that IFNL4 genotypes determine HCV viral load through a mechanism that is dependent on a specific polymorphism in the HCV polyprotein. We highlight the interplay between innate immune responses and the viral genome in HCV control.
AU - Ansari,A
AU - Pedergnana,V
AU - Ip,C
AU - Magri,A
AU - von,Delft A
AU - Bonsall,D
AU - Chaturvedi,N
AU - Bartha,I
AU - Smith,D
AU - Nicholson,D
AU - McVean,G
AU - Trebes,A
AU - Piazza,P
AU - Fellay,J
AU - Cooke,GS
AU - Foster,G
AU - STOPHCV,consortium
AU - Hudson,E
AU - McLauchlan,J
AU - Simmonds,P
AU - Bowden,R
AU - Klenerman,P
AU - Barnes,E
AU - Spencer,C
DO - 10.1038/ng.3835
EP - 673
PY - 2017///
SN - 1546-1718
SP - 666
TI - Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus
T2 - Nature Genetics
UR - http://dx.doi.org/10.1038/ng.3835
VL - 49
ER -