1. Research Associate in Cardiovascular Regeneration

DR Helle JørgenSEN, University of Cambridge, UK

Applications are invited for a three-year postdoctoral Research Associate post in the group of Dr Helle Jørgensen in the Division of Cardiovascular Medicine, University of Cambridge. 

 This post is funded by the British Heart Foundation Centre of Regenerative Medicine. The Centre  was established in 2013 as one of three national research hubs specialising in cardiovascular regeneration. Membership of the Centre provides a unique opportunity to collaborate with researchers across the partnership. Annual review meetings and cross-Centre events present opportunities for discussion and showcasing of the research.

The Jørgensen group studies regulation of cell plasticity and heterogeneity in regeneration and disease development with a particular focus on proliferative responses (see Circ Res. 2016; CIRCRESAHA.116.309799). We use clonal lineage tracing in animal models and single cell RNA-sequencing combined with other molecular techniques and are looking for a highly motivated and creative individual to join our team. The focus of the project will be on signalling and transcriptional networks regulating vascular smooth muscle cell proliferation.

The successful applicant will have a PhD (or equivalent) in a relevant subject and must have experience in cell and molecular biology. Additionally, the applicant must have communication and organisational skills. Experience with genomics data analysis, development of high throughput assays and/or using animal models is desirable but not essential. 

Please contact Dr Helle Jørgensen (tel: +44 (0)1223 762581, e-mail: hfj22@cam.ac.uk) for informal enquiries about this post. 

The funds for this post are available for 3 years in the first instance. Closing date for applications is the 2nd May 2018.

Applications should be submitted online here, quoting reference RC15216. Please ensure that you upload a covering letter and CV in the Upload section of the online application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

2. Postdoctoral Researcher in Developmental Epigenetics

Dr Ramalho-santos lab, university of toronto, canada

We are recruiting postdoctoral fellows effective immediately to join the Dr Ramalho-Santos Lab in Lunenfeld-Tanenbaum Research Institute (LTRI) at the University of Toronto. Dr Ramalho-Santos will be the Canada 150 Research Chair in Developmental Epigenetics and lead an exciting new initiative in this area in Toronto.

• The LTRI is the top biomedical research institute in Canada
• The LTRI has major strengths in Systems Biology and Developmental and Stem Cell Biology.
• The lab will be supported by stellar core facilities for sequencing, proteomics, imaging, flow cytometry,metabolomics
• The LTRI has one of the best academic mouse facilities in North America 
• The University of Toronto is one of the top 20 universities in the world. In one single campus in downtown Toronto there is arguably the highest concentration of top biomedical research in North America.
• Very interactive & collaborative community.

Toronto is a vibrant, cosmopolitan, diverse, liberal and safe city.

• Excellent quality of life 
• Great cultural offer, professional sports, restaurants, parks, schools and public transit. Low crime.
• Nearby: good hiking, camping, biking, water sports, cross-country skiing, etc.
• Very easy to travel to/from with 2 modern airports with connections all over the world.
• Direct flights to all major cities in US, Europe, Asia.
• Rent in Toronto are much more affordable than San Francisco or Boston
• Large city with many opportunities for spouses/partners in academic labs, hospitals, biotech, pharma, etc.

Preference will be giving to candidates with a strong published record in several of these areas:

• Developmental Biology, Fertilization, Pre-Implantation Development, Pluripotency, Germline Development,
• Embryonic and Adult Stem Cell Biology, DNA Methylation, Chromatin Biology, Non-Coding RNAs,
• Epigenomics, Transgenerational Epigenetic Inheritance, Functional Genomics, Genome Editing,
• Transposon Biology, Nuclear Dynamics, Bioinformatics
• Qualified candidates should send a CV, cover letter detailing research experience and how their interests fit with the broad field of Developmental Epigenetics, and the names of 3 references to mrsantos@ucsf.edu

3. Postdoctoral Researchers in Stem Cell Epigenetics

PABLO NAVARRO LAB, INSTITUT PASTEUR, PARIS

The Epigenetics of Stem Cells lab is using a combination of chromatin biology, cell biology and computational sciences to understand how mitosis impacts gene regulatory processes in pluripotent cells. We are now expanding our work to other stem cell populations and early mouse embryos. Within the framework of an ERC Consolidator grant we are hiring three Post-Doctoral researchers, as detailed below. This project requires particularly original and open-minded scientists to develop new ideas regarding how the functional interplay between mitotic regulators, transcription factors and chromatin states, influence cell identity. We expect the successful candidates to be capable of working autonomously and develop their own line of research within the framework of our goals and scientific interests. 

The global aim of our project is to tackle a major question in stem cell and developmental biology: how do Transcription Factors (TFs) maintain cell identities? We study this question from the perspective of mitotic bookmarking: our hypothesis is that this represents a key process impacting cell fate acquisition and maintenance, epigenetic regulation across all forms of chromatin and, finally, the mechanisms of mitosis. The model of choice, early embryonic development and its associated stem cells, focus this question on the role of these mechanisms in vivo. We plan to study a wide range of phenomena from the local state of nucleosomes to the dynamics of a network. Notably, we will weigh the contribution and relationships of epigenetic regulation and bookmarking TFs in the context of euchromatin and heterochromatin.

To achieve our aims we invite Post-Doc applications to study: 

1. How the fundamental mechanisms of mitosis are connected to gene regulatory events during cell division. The successful candidate will hold a PhD in Cell Biology and will preferentially be experienced in the study of mitosis. Previous training in microscopy and imaging will be an asset. 

2. How the properties of the chromatin during mitosis are controlled by TFs and how this impacts gene regulation during and after cell division. The successful candidate will hold a PhD in Molecular Biology or Biochemistry and should have a strong background in epigenomics. 

3. How mitosis influences gene expression during self-renewal, differentiation and development. The successful candidate will hold a PhD in Computational Sciences and be experienced in Omics data analysis. A strong background in modeling and statistics will be positively evaluated. 

Starting after September 2018, the appointments will be made for 30 months. Successful candidates may apply to independent fellowships; at least one 1st author paper from their PhD is mandatory. They will work in collaboration with Master/PhD students to get training in mentoring and research organization. Successful candidates should be strongly motivated, highly collaborative, and have good communication skills in English. We offer a competitive salary according to Institut Pasteur standards, excellent working conditions, and an intellectually rich environment in the dynamic city of Paris. 

Applications should be submitted to pablo.navarro-gil@pasteur.fr and include a cover letter describing your interest in the position, a detailed CV, a brief description of previous research (below 1 page), publications list, plus the contact details of at least two referees.