guy poncing

Synthetic Biology underpins advances in the bioeconomy

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology. 

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Critchley:2018:10.3389/fphys.2018.00559,
author = {Critchley, B and Isalan, M and Mielcarek, M},
doi = {10.3389/fphys.2018.00559},
journal = {Frontiers in Physiology},
title = {Neuro-Cardio mechanisms in Huntington’s disease and other neurodegenerative disorders},
url = {http://dx.doi.org/10.3389/fphys.2018.00559},
volume = {9},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Although Huntington’s disease is generally considered to be aneurological disorder, there is mounting evidence that heart malfunction plays an important role in disease progression. This is perhaps not unexpected since both cardiovascular and nervous systems are strongly connected—both development ally and subsequently inhealth and disease. This connection occurs through a systemof central and peripheral neurons that control cardiovascular performance, while in return the cardiovascular system worksas a sensor for the nervous system to react to physiological events. Hence, given their permanent interconnectivity, any pathological events occurring in one system might affect the second. In addition, some pathological signals fromHuntington’s disease might occur simultaneously in both the cardiovascular and nervous systems, since mutant Huntingtin protein is expressedin both. Here we aim to review the source of HD-related cardiomyopathy in the light of recently-published studies, and to identify similarities between HD-related cardiomyopathy andother neuro-cardio disorders.
AU - Critchley,B
AU - Isalan,M
AU - Mielcarek,M
DO - 10.3389/fphys.2018.00559
PY - 2018///
SN - 1664-042X
TI - Neuro-Cardio mechanisms in Huntington’s disease and other neurodegenerative disorders
T2 - Frontiers in Physiology
UR - http://dx.doi.org/10.3389/fphys.2018.00559
UR - http://hdl.handle.net/10044/1/59337
VL - 9
ER -

logo

What's going on? Take a look at our events

Funders

Work in the IC-CSynB is supported by a wide range of Research Councils, Learned Societies, Charities and more.