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@article{Zhang:2022:10.1039/D2CC03092F,
author = {Zhang, Q and Kounde, C and Mondal, M and Zhang, L and Conole, D and De, Vita E and Fuchter, M and Tate, E},
doi = {10.1039/D2CC03092F},
journal = {Chemical Communications},
pages = {10933--10936},
title = {Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)},
url = {http://dx.doi.org/10.1039/D2CC03092F},
volume = {58},
year = {2022}
}
TY - JOUR
AB - Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.
AU - Zhang,Q
AU - Kounde,C
AU - Mondal,M
AU - Zhang,L
AU - Conole,D
AU - De,Vita E
AU - Fuchter,M
AU - Tate,E
DO - 10.1039/D2CC03092F
EP - 10936
PY - 2022///
SN - 1359-7345
SP - 10933
TI - Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
T2 - Chemical Communications
UR - http://dx.doi.org/10.1039/D2CC03092F
UR - http://pubs.rsc.org/en/content/articlehtml/2022/cc/d2cc03092f
UR - http://hdl.handle.net/10044/1/99433
VL - 58
ER -