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BibTex format

author = {Dang, THT and Fagan, RP and Fairweather, NF and Tate, EW},
doi = {10.1016/j.bmc.2011.06.042},
journal = {Bioorganic & Medicinal Chemistry},
pages = {614--621},
title = {Novel inhibitors of surface layer processing in Clostridium difficile},
url = {},
volume = {20},
year = {2012}

RIS format (EndNote, RefMan)

AB - Clostridium difficile, a leading cause of hospital-acquired bacterial infection, is coated in a dense surface layer (S-layer) that is thought to provide both physicochemical protection and a scaffold for host-pathogen interactions. The key structural components of the S-layer are two proteins derived from a polypeptide precursor, SlpA, via proteolytic cleavage by the protease Cwp84. Here, we report the design, synthesis and in vivo characterization of a panel of protease inhibitors and activity-based probes (ABPs) designed to target S-layer processing in live C. difficile cells. Inhibitors based on substrate-mimetic peptides bearing a C-terminal Michael acceptor warhead were found to be promising candidates for further development.
AU - Dang,THT
AU - Fagan,RP
AU - Fairweather,NF
AU - Tate,EW
DO - 10.1016/j.bmc.2011.06.042
EP - 621
PY - 2012///
SN - 1464-3391
SP - 614
TI - Novel inhibitors of surface layer processing in Clostridium difficile
T2 - Bioorganic & Medicinal Chemistry
UR -
UR -
VL - 20
ER -