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@article{Clulow:2017:10.1039/c6cc08797c,
author = {Clulow, JA and Storck, EM and Lanyon-Hogg, T and Kalesh, KA and Jones, LH and Tate, EW},
doi = {10.1039/c6cc08797c},
journal = {Chemical Communications},
pages = {5182--5185},
title = {Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane},
url = {http://dx.doi.org/10.1039/c6cc08797c},
volume = {53},
year = {2017}
}
TY - JOUR
AB - Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.
AU - Clulow,JA
AU - Storck,EM
AU - Lanyon-Hogg,T
AU - Kalesh,KA
AU - Jones,LH
AU - Tate,EW
DO - 10.1039/c6cc08797c
EP - 5185
PY - 2017///
SN - 1364-548X
SP - 5182
TI - Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
T2 - Chemical Communications
UR - http://dx.doi.org/10.1039/c6cc08797c
UR - http://hdl.handle.net/10044/1/48122
VL - 53
ER -
Prof. Ed Tate
GSK Chair in Chemical Biology
Department of Chemistry
Molecular Sciences Research Hub, White City Campus,
82 Wood Lane, London, W12 0BZ
e.tate@imperial.ac.uk
Tel: +44 (0)20 759 + ext 43752 or 45821