The Network aims to promote multi-disciplinary approaches to address challenging vaccine-related questions. This page contains a curated list of publications that highlight high-impact and collaborative approaches.

Citation

BibTex format

@article{Mehring-Le:2017:10.1016/j.vaccine.2017.04.013,
author = {Mehring-Le, Doare KEK},
doi = {10.1016/j.vaccine.2017.04.013},
journal = {Vaccine},
pages = {2970--2978},
title = {Association between functional antibody against Group B Streptococcus and maternal and infant colonization in a Gambian cohort},
url = {http://dx.doi.org/10.1016/j.vaccine.2017.04.013},
volume = {35},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BackgroundVertical transmission of Group B Streptococcus (GBS) is a prerequisite for early-onset disease and a consequence of maternal GBS colonization. Disease protection is associated with maternally-derived anti-GBS antibody. Using a novel antibody-mediated C3b/iC3b deposition flow cytometry assay which correlates with opsonic killing we developed a model to assess the impact of maternally-derived functional anti-GBS antibody on infant GBS colonization from birth to day 60–89 of life.MethodsRectovaginal swabs and cord blood (birth) and infant nasopharyngeal/rectal swabs (birth, day 6 and day 60–89) were obtained from 750 mother/infant pairs. Antibody-mediated C3b/iC3b deposition with cord and infant sera was measured by flow cytometry.ResultsWe established that as maternally-derived anti-GBS functional antibody increases, infant colonization decreases at birth and up to three months of life, the critical time window for the development of GBS disease. Further, we observed a serotype (ST)-dependent threshold above which no infant was colonized at birth. Functional antibody above the upper 95th confidence interval for the geometric mean concentration was associated with absence of infant GBS colonization at birth for STII (p < 0.001), STIII (p = 0.01) and STV (p < 0.001). Increased functional antibody was also associated with clearance of GBS between birth and day 60–89.ConclusionsHigher concentrations of maternally-derived antibody-mediated complement deposition are associated with a decreased risk of GBS colonization in infants up to day 60–89 of life. Our findings are of relevance to establish thresholds for protection following vaccination of pregnant women with future GBS vaccines.
AU - Mehring-Le,Doare KEK
DO - 10.1016/j.vaccine.2017.04.013
EP - 2978
PY - 2017///
SN - 1873-2518
SP - 2970
TI - Association between functional antibody against Group B Streptococcus and maternal and infant colonization in a Gambian cohort
T2 - Vaccine
UR - http://dx.doi.org/10.1016/j.vaccine.2017.04.013
UR - http://hdl.handle.net/10044/1/46236
VL - 35
ER -