The Vascular Science Network is interested in providing positions for talented researchers specifically in vascular disease, haemostasis and related fields. Please see further information below on our currently available positions.
Opening for a Post-doc or Technician in the Vascular Sciences Section
24 February 2021: Endothelial colony-forming cells in rheumatoid arthritis
There is an opening for a post-doc or technician in the Vascular Sciences Section, NHLI, ICTEM Building, Hammersmith Campus. Patients with rheumatoid arthritis (RA) are at increased risk of cardiovascular mortality. Although inflammatory-mediated vascular dysfunction may play a significant role, no clinical test is routinely used to incorporate this parameter into cardiovascular risk prediction. In this novel study, the aim is to further our understanding of how inflammation and treatment affect the endothelium in vivo by evaluating endothelial colony-forming cell (ECFC) frequency and phenotype in active RA patients, before and after initiation of immunomodulatory treatment. Derived from peripheral blood, ECFC has been proposed as a novel marker of ongoing vascular injury and repair.
The successful candidate will be responsible for designing and executing experiments with ECFC isolated from patients with RA and healthy control volunteers, and employ a variety of functional and molecular methods including cell proliferation, endothelial tube formation and inflammatory assays.