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• Journal article
  He X, Herranz F, Cheng EC-C, Vilar R, Yam VW-Wet al., 2010,

  Design, Synthesis, Photophysics, and Anion-Binding Studies of Bis(dicyclohexylphosphino)methane-Containing Dinuclear Gold(I) Thiolate Complexes with Urea Receptors

  , CHEMISTRY-A EUROPEAN JOURNAL, Vol: 16, Pages: 9123-9131, ISSN: 0947-6539
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  • Citations: 47
• Journal article
  Suntharalingam K, Gupta D, Miguel PJS, Lippert B, Vilar Ret al., 2010,

  Synthesis, Structural Characterisation and Quadruplex DNA Binding Studies of a New Gold(III) Pyrazolylpyridine Complex

  , CHEMISTRY-A EUROPEAN JOURNAL, Vol: 16, Pages: 3613-3616, ISSN: 0947-6539
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  • Citations: 27
• Journal article
  Georgiades SN, Abd Karim NH, Suntharalingam K, Vilar Ret al., 2010,

  Interaction of Metal Complexes with G-Quadruplex DNA

  , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 49, Pages: 4020-4034, ISSN: 1433-7851
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  • Citations: 394
• Journal article
  Owen GR, White AJP, Vilar R, 2009,

  Palladium Iminoacyl Imine Complexes: Strategies toward Imine Insertion

  , ORGANOMETALLICS, Vol: 28, Pages: 5783-5793, ISSN: 0276-7333
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  • Citations: 9
• Journal article
  Suntharalingam K, White AJP, Vilar R, 2009,

  Synthesis, Structural Characterization, and Quadruplex DNA Binding Studies of Platinum(II)-Terpyridine Complexes

  , INORGANIC CHEMISTRY, Vol: 48, Pages: 9427-9435, ISSN: 0020-1669
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  • Citations: 73
• Journal article
  Barry NPE, Abd Karim NH, Vilar R, Therrien Bet al., 2009,

  Interactions of ruthenium coordination cubes with DNA

  , DALTON TRANSACTIONS, Pages: 10717-10719, ISSN: 1477-9226
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  • Citations: 77
• Journal article
  Reed JE, White AJP, Neidle S, Vilar Ret al., 2009,

  Effect of metal coordination on the interaction of substituted phenanthroline and pyridine ligands with quadruplex DNA

  , DALTON TRANSACTIONS, Pages: 2558-2568, ISSN: 1477-9226
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  • Citations: 59
• Journal article
  Miller PW, Jennings LE, deMello AJ, Gee AD, Long NJ, Vilar Ret al., 2009,

  A microfluidic approach to the rapid screening of palladium catalysed aminocarbonylation reactions

  , Advanced Synthesis and Catalysis, Vol: 351, Pages: 3260-3268
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• Journal article
  Mendoza C, Benet-Buchholz J, Pericas MA, Vilar Ret al., 2009,

  Di-platinum complexes containing thiolato-urea ligands: structural and anion binding studies

  , DALTON TRANSACTIONS, Pages: 2974-2985, ISSN: 1477-9226
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  • Citations: 5
• Conference paper
  Miller P, Long N, Vilar R, de Mello A, Gee A, Bender D, Audrain H, Golonka L, Malecha Ket al., 2009,

  NOVEL MICROREACTOR TECHNOLOGIES FOR 11C RADIOLABELLING

  , Publisher: WILEY, Pages: S13-S13, ISSN: 0362-4803
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• Journal article
  Vilar R, 2009,

  Bioinorganic chemistry

  , ANNUAL REPORTS ON THE PROGRESS OF CHEMISTRY, VOL 105, SECTION A: INORGANIC CHEMISTRY, Vol: 105, Pages: 477-504, ISSN: 0260-1818
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  • Citations: 2
• Journal article
  Arola-Arnal A, Benet-Buchholz J, Neidle S, Vilar Ret al., 2008,

  Effects of Metal Coordination Geometry on Stabilization of Human Telomeric Quadruplex DNA by Square-Planar and Square-Pyramidal Metal Complexes

  , INORGANIC CHEMISTRY, Vol: 47, Pages: 11910-11919, ISSN: 0020-1669
  • Author Web Link
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  • Citations: 112
• Journal article
  Herranz F, Puerto Morales M, Roca AG, Vilar R, Ruiz-Cabello Jet al., 2008,

  A new method for the aqueous functionalization of superparamagnetic Fe₂O₃ nanoparticles

  , CONTRAST MEDIA & MOLECULAR IMAGING, Vol: 3, Pages: 215-222, ISSN: 1555-4309
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  • Citations: 21
• Journal article
  Miller PW, Long NJ, Vilar R, Gee ADet al., 2008,

  Synthetic radiolabelling strategies for radiotracers in Positron Emission Tomography (PET) imaging

  , Angewandte Chemie Int. Ed., Vol: 47, Pages: 8998-9033
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• Journal article
  Arola A, Vilar R, 2008,

  Stabilisation of G-Quadruplex DNA by Small Molecules

  , CURRENT TOPICS IN MEDICINAL CHEMISTRY, Vol: 8, Pages: 1405-1415, ISSN: 1568-0266
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  • Citations: 119
• Journal article
  Reed J, Gunaratnam M, Beltran M, Reszka AP, Vilar R, Neidle Set al., 2008,

  TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules

  , ANALYTICAL BIOCHEMISTRY, Vol: 380, Pages: 99-105, ISSN: 0003-2697
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  • Citations: 98
• Conference paper
  Long NJ, Miller PW, de Mello A, Vilar R, Gee ADet al., 2008,

  INOR 301-New strategies for 11-carbon labeling in PET: From fast synthesis to microfluidics

  , 236th National Meeting of the American-Chemical-Society, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
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• Book
  Vilar R, 2008,

  Structure and Bonding: Preface

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  • Citations: 11
• Journal article
  Vilar R, 2008,

  Anion recognition and templation in coordination chemistry

  , EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Pages: 357-367, ISSN: 1434-1948
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  • Citations: 111
• Journal article
  Vilar R, 2008,

  Anion templates in synthesis and dynamic combinatorial libraries

  , RECOGNITION OF ANIONS, Vol: 129, Pages: 175-206, ISSN: 0081-5993
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  • Citations: 89
• Journal article
  Gimeno N, Li X, Durrant JR, Vilar Ret al., 2008,

  Cyanide sensing with organic dyes:: Studies in solution and on nanostructured Al₂O₃ surfaces

  , CHEMISTRY-A EUROPEAN JOURNAL, Vol: 14, Pages: 3006-3012, ISSN: 0947-6539
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  • Citations: 175
• Journal article
  Tovilla JA, Carlqvist P, Benet-Buchholz J, Maseras F, Vilar Ret al., 2007,

  Di-palladium complexes with urea-containing ligands as anion receptors

  , SUPRAMOLECULAR CHEMISTRY, Vol: 19, Pages: 599-611, ISSN: 1061-0278
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  • Citations: 9
• Book chapter
  Vilar R, 2007,

  PET Imaging in Chemical Biology

  , Chemical Biology: Applications and Techniques, Pages: 217-229
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• Journal article
  Gimeno N, Formentin P, Steinke JHG, Vilar Ret al., 2007,

  Phenylphosphoric acid as a new additive to inhibit olefin isomerisation in ruthenium-catalysed metathesis reactions

  , EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol: 2007, Pages: 918-924, ISSN: 1434-193X
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  • Citations: 32
• Journal article
  Shalom D, Wootton RCR, Winkle RF, Cottam BF, Vilar R, deMello AJ, Wilde CPet al., 2007,

  Synthesis of thiol functionalized gold nanoparticles using a continuous flow microfluidic reactor

  , MATERIALS LETTERS, Vol: 61, Pages: 1146-1150, ISSN: 0167-577X
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  • Citations: 98
• Journal article
  Reed JE, Neidle S, Vilar R, 2007,

  Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex

  , CHEMICAL COMMUNICATIONS, Pages: 4366-4368, ISSN: 1359-7345
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  • Citations: 99
• Journal article
  Miller PW, Long NJ, de Mello AJ, Vilar R, Audrain H, Bender D, Passchier J, Gee Aet al., 2007,

  Rapid multiphase carbonylation reactions using a micro-tube reactor: Applications in Positron Emission Tomography (PET) 11C-Radiolabelling

  , Angewandte Chemie International Edition, Vol: 46, Pages: 2875-2878
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• Journal article
  Diaz P, Tovilla JA, Ballester P, Benet-Buchholz J, Vilar Ret al., 2007,

  Synthesis, structural characterization and anion binding studies of palladium macrocycles with hydrogen-bonding ligands

  , DALTON TRANSACTIONS, Pages: 3516-3525, ISSN: 1477-9226
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  • Citations: 27
• Journal article
  Christmann U, Pantazis DA, Benet-Buchholz J, McGrady JE, Maseras F, Vilar Ret al., 2006,

  Synthesis and computational studies of palladium(I) dimers Pd₂X₂(P<i><SUP>t</SUP></i>Bu₂Ph)₂ (X = Br, I):: Phenyl versus halide bridging modes

  , ORGANOMETALLICS, Vol: 25, Pages: 5990-5995, ISSN: 0276-7333
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  • Citations: 20
• Journal article
  Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EW, Vilar R, Woscholski Ret al., 2006,

  A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN)

  , ACS Chem.Biol., Vol: 1, Pages: 780-790

  Phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes. Here we report the design and validation of a small- molecule inhibitor of PTEN. Compared with other cysteine-based phosphatases, PTEN has a much wider active site cleft enabling it to bind the PtdIns(3,4,5)P3 substrate. We have exploited this feature in the design of vanadate scaffolds complexed to a range of different organic ligands, some of which show potent inhibitory activity. A vanadyl complexed to hydroxypicolinic acid was found to be a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations. The findings presented here demonstrate the applicability of a novel and specific chemical inhibitor against PTEN in research and drug development

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