In this section
@article{Stafford:2014:10.1039/c4dt02910k,
author = {Stafford, VS and Suntharalingam, K and Shivalingam, A and White, AJP and Mann, DJ and Vilar, R},
doi = {10.1039/c4dt02910k},
journal = {Dalton Transactions},
pages = {3686--3700},
title = {Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA},
url = {http://dx.doi.org/10.1039/c4dt02910k},
volume = {44},
year = {2014}
}
TY - JOUR
AB - A series of mono- and bi-metallic metal complexes (with CuII, PtII and ZnII) with substituted polypyridylligands have been prepared and their binding affinities towards quadruplex (c-Myc and human telomeric)and duplex DNA (ds26 and calf thymus) determined using fluorescent indicator displacement (FID) assaysand UV/vis spectroscopic titrations. These studies have shown that the number of aromatic rings andnumber/position of cyclic amine substituents on the ligands, play an important role in defining the DNAbinding abilities of the resulting metal complexes. We also show that bi-metallic complexes preparedusing a novel terpyridine-cyclen ligand have higher affinity towards G-quadruplex DNA as compared totheir mono-metallic counterparts. Cytotoxicity assays were carried out for all the new complexes againstan osteosarcoma cancer cell line (U2OS) as well as a normal fibroblast cell line (GM05757). Several ofthese compounds displayed cytotoxicity similar to that of cisplatin.
AU - Stafford,VS
AU - Suntharalingam,K
AU - Shivalingam,A
AU - White,AJP
AU - Mann,DJ
AU - Vilar,R
DO - 10.1039/c4dt02910k
EP - 3700
PY - 2014///
SN - 1477-9226
SP - 3686
TI - Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA
T2 - Dalton Transactions
UR - http://dx.doi.org/10.1039/c4dt02910k
UR - http://hdl.handle.net/10044/1/25630
VL - 44
ER -