In this section
Some of the covers featuring our work are shown below:
Wilton-Ely J, 2006, Dinuclear ruthenium and osmium compounds with metal-metal bonds, Comprehensive Organometallic Chemistry III, Editor(s): Crabtree, Mingos, Elsevier, Pages:647-716, ISBN:978-0080445908
@article{Farah:2025:10.1002/anbr.202500230,
author = {Farah, F and Qin, Y and Shi, X and Owen, D and Green, M and Wilton-Ely, J},
doi = {10.1002/anbr.202500230},
journal = {Advanced Biomedical Research},
title = {Dual modality semiconducting polymer nanoparticles for use in optical and magnetic resonance imaging},
url = {http://dx.doi.org/10.1002/anbr.202500230},
year = {2025}
}
TY - JOUR
AB - Semiconducting polymer nanoparticles (SPNs) hold great promise as fluorescent nanoparticles with many advantageous optical and biological properties. However, their potential for optical imaging in clinical applications is currently restricted by limited tissue penetration, compared to the depth offered by magnetic resonance imaging (MRI). Multimodal SPN-based contrast agents that integrate different, complementary imaging modalities into one platform allow the strengths to be combined and the weaknesses mitigated. This study presents an accessible route to modular, well-defined and versatile dual modality SPNs composed of red-emitting SPNs functionalised with novel gadolinium-based contrast agents (GBCA). The Gd unit is attached to the surface of the SPN using a rigid linker, providing a robust attachment point as well as enhancing the MRI performance. Preliminary in vitro studies show that the SPNs are non-toxic across all concentrations tested and readily taken up by cells, illustrating their potential as imaging probes. Anchoring the GBCA unit to the surface of the SPN yielded a dramatic increase in the relaxivity compared to the unattached contrast agent unit. The dual modality probe showed a four-fold relaxivity enhancement over the clinical standard, Dotarem, at clinical field strengths, making this dual modality platform a promising design for combined optical and MR imaging.
AU - Farah,F
AU - Qin,Y
AU - Shi,X
AU - Owen,D
AU - Green,M
AU - Wilton-Ely,J
DO - 10.1002/anbr.202500230
PY - 2025///
SN - 2277-9175
TI - Dual modality semiconducting polymer nanoparticles for use in optical and magnetic resonance imaging
T2 - Advanced Biomedical Research
UR - http://dx.doi.org/10.1002/anbr.202500230
ER -