In this section
Some of the covers featuring our work are shown below:
Wilton-Ely J, 2006, Dinuclear ruthenium and osmium compounds with metal-metal bonds, Comprehensive Organometallic Chemistry III, Editor(s): Crabtree, Mingos, Elsevier, Pages:647-716, ISBN:978-0080445908
@article{Robson:2026,
author = {Robson, J and Hendley, R and Kubankova, M and James, S and Garcia-Giner, V and Kuimova, M and Wilton-Ely, J},
journal = {Advanced Sensor Research},
title = {Ruthenium(II) and osmium(II) probes based on the BODIPY fluorophore for the detection of carbon monoxide and viscosity in biological environments},
year = {2026}
}
TY - JOUR
AB - Carbon monoxide (CO) detection in biological environments requires robust, well-defined probes that react rapidly and selectively with CO to deliver a fluorescence response. A pyridyl BODIPY fluorophore was used to prepare a family of ruthenium and osmium vinyl complexes. Modification with water-solubilising units resulted in improved compatibility with aqueous media. When the BODIPY fluorophore was attached to the metal centre through the vinyl ligand, its emission was initially quenched. Reaction with CO caused a revival in the emission, providing a highly sensitive mechanism for detection of this analyte. The probes showed excellent stability and selectivity for CO over other species present in the cellular matrix and showed no toxicity at the concentrations used for sensing. The most effective CO probe displayed a 24-fold increase in fluorescence when treated with CO. This led to experiments in cellulo which revealed that the CO produced by an increase in HO-1 activity under hypoxic conditions could be detected. One of the complex designs was used as a viscosity-sensitive molecular rotor, providing localised viscosity information. This led to the first demonstration of simultaneous CO and viscosity measurement, which revealed that an increase in heme oxygenase 1 (HO-1) expression caused a decrease in cellular viscosity.
AU - Robson,J
AU - Hendley,R
AU - Kubankova,M
AU - James,S
AU - Garcia-Giner,V
AU - Kuimova,M
AU - Wilton-Ely,J
PY - 2026///
SN - 2751-1219
TI - Ruthenium(II) and osmium(II) probes based on the BODIPY fluorophore for the detection of carbon monoxide and viscosity in biological environments
T2 - Advanced Sensor Research
ER -