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Journal articleNagel G, Chen J, Jaensch A, et al., 2024,
Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: the ELAPSE project
, International Journal of Cancer, Vol: 154, Pages: 1900-1910, ISSN: 0020-7136Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM2.5 ), nitrogen dioxide (NO2 ), black carbon (BC) and ozone in the warm season (O3w ) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. During 5,305,133 and 5,434,843 person-years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM2.5 , NO2 and BC while for UADT the hazard ratios (95% confidence interval) were 1.15 (95% CI: 1.00-1.33) per 5 μg/m3 increase in PM2.5 , 1.19 (1.08-1.30) per 10 μg/m3 increase in NO2 , 1.14 (1.04-1.26) per 0.5 × 10-5 m-1 increase in BC and 0.81 (0.72-0.92) per 10 μg/m3 increase in O3w . We found no association between long-term ambient air pollution exposure and incidence of gastric cancer, while for long-term exposure to PM2.5 , NO2 and BC increased incidence of UADT cancer was observed.
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Journal articleGriffiths A, Lambelet M, Crocket K, et al., 2024,
Neodymium isotope composition and rare earth element distribution of East Antarctic continental shelf and deep waters
, Chemical Geology, Vol: 653, ISSN: 0009-2541Circumpolar Deep Water (CDW) and Antarctic Bottom Water (AABW) play key roles in the Earth's climate system. Both water masses form critical components of the Antarctic Circumpolar Current and Meridional Overturning Circulation and therefore directly influence the large-scale redistribution of heat, nutrients and carbon. Reconstruction of past CDW transport and AABW production and export has been a key target in palaeoceanography. One promising proxy to achieve this has been the neodymium (Nd) isotope composition of seawater. The biogeochemical processes controlling Nd in the ocean, however, remain underconstrained, and modern observations of Nd isotopes in the Southern Ocean are still geographically limited.To overcome this limitation, 61 seawater samples were collected for Nd isotope and rare earth element (REE) analysis at nine stations along the Wilkes Land continental margin and in the Australian-Antarctic Basin (65°S 125°E) near East Antarctica. The results show that the different water masses have the following Nd isotope characteristics: Antarctic Surface Water (AASW), εNd = −9.0 ± 1.0 (2SD; n = 22); Modified CDW (MCDW), εNd = −8.8 ± 0.8 (2SD; n = 22); AABW, εNd = −8.3 ± 0.5 (2SD; n = 17).There is no evidence of continental REE inputs to surface waters on the Wilkes Land margin. Observed zonal variability of Nd isotope composition in AASW can be attributed to seasonal competition between the poleward flow of warm AASW from the AAG and the westward export of cold surface shelf waters by the Antarctic Slope Current.In terms of deep and bottom waters, mixing of upwelled CDW with AASW and AABW exclusively controls the Nd isotope composition of MCDW, with no indication of boundary processes modifying the Nd isotope composition of MCDW as it encroaches the shelf or slope. The regional Nd isotope signature for AABW is intermediate between published data for the Atlantic sector AABW (εNd
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Journal articleHan W, Zhang J, Xu Z, et al., 2024,
Could the association between ozone and arterial stiffness be modified by fish oil supplementation?
, Environmental Research, Vol: 249, ISSN: 0013-9351BACKGROUND: Arterial stiffness (AS) is an important predicting factor for cardiovascular disease. However, no epidemiological studies have ever explored the mediating role of biomarkers in the association between ozone and AS, nor weather fish oil modified such association. METHODS: Study participants were drawn from the UK biobank, and a total of 95,699 middle-aged and older adults were included in this study. Ozone was obtained from Community Multiscale Air Quality (CMAQ) model matched to residential addresses, fish oil from self-reported intake, and arterial stiffness was based on device measurements. First, we applied a double robust approach to explore the association between ozone or fish oil intake and arterial stiffness, adjusting for potential confounders at the individual and regional levels. Then, how triglycerides, apolipoprotein B (Apo B)/apolipoprotein A (ApoA) and non-high-density lipoprotein cholesterol (Non-HDL-C) mediate the relationship between ozone and AS. Last, the modifying role of fish oil was further explored by stratified analysis. RESULTS: The mean age of participants was 55 years; annual average ozone exposure was associated with ASI (beta:0.189 [95%CI: 0.146 to 0.233], P < 0.001), and compared to participants who did not consume fish oil, fish oil users had a lower ASI (beta: 0.061 [95%CI: -0.111 to -0.010], P = 0.016). The relationship between ozone exposure and AS was mediated by triglycerides, ApoB/ApoA, and Non-HDL-C with mediation proportions ranging from 10.90% to 18.30%. Stratified analysis showed lower estimates on the ozone-AS relationship in fish oil users (P = 0.011). CONCLUSION: Ozone exposure was associated with higher levels of arterial stiffness, in contrast to fish oil consumption, which showed a protective association. The association between ozone exposure and arterial stiffness was partially mediated by some biomarkers. In the general population, fish oil consumption might provide prote
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Journal articleHu S, Shu S, Chen Z, et al., 2024,
Sustainable impact analysis of freight pooling strategies on city crowdsourcing logistics platform
, Transportation Research Part D: Transport and Environment, Vol: 130, ISSN: 1361-9209This study investigates the effects of freight pooling strategies on urban crowdsourcing logistics, focusing on economic, social, and environmental outcomes. Utilising a mixed-integer linear programming model with an adaptive large neighbourhood search algorithm, our goal is to optimise the cost-efficiency of the freight pooling system. Real-world delivery and driver trajectory data from a major Chinese crowdsourcing logistics platform, along with high-resolution vehicle telematics data, validate our model in five scenarios, each defined by distinct cost coefficients reflecting diverse stakeholder priorities. Results show potential for up to a 21.3% reduction in carbon emissions, a 28.3% decrease in truck activity spatial coverage, and a 7.6% increase in available drivers. However, deadheading trips, due to order consolidation into fewer vehicles without an increase in overall demand, could offset maximum carbon reduction benefits by 16.4%. Other effects on customers’ and drivers’ welfare are explored for a comprehensive quantitative assessment of freight pooling strategies’ sustainability benefits.
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Journal articleHazzard JAN, Richards FD, 2024,
Antarctic Geothermal Heat Flow, Crustal Conductivity and Heat Production Inferred From Seismological Data
, Geophysical Research Letters, Vol: 51, ISSN: 0094-8276Geothermal heat flow is a key parameter in governing ice dynamics, via its influence on basal melt and sliding, englacial rheology, and erosion. It is expected to exhibit significant lateral variability across Antarctica. Despite this, surface heat flow derived from Earth's interior remains one of the most poorly constrained parameters controlling ice sheet evolution. To obtain a continent-wide map of Antarctic heat supply at regional-scale resolution, we estimate upper mantle thermomechanical structure directly from VS. Until now, direct inferences of Antarctic heat supply have assumed constant crustal composition. Here, we explore a range of crustal conductivity and radiogenic heat production values by fitting thermodynamically self-consistent geotherms to their seismically inferred counterparts. Independent estimates of crustal conductivity derived from VP are integrated to break an observed trade-off between crustal parameters, allowing us to infer Antarctic geothermal heat flow and its associated uncertainty.
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Journal articleVicco A, McCormack C, Pedrique B, et al., 2024,
A scoping literature review of global dengue age-stratified seroprevalence data: estimating dengue force of infection in endemic countries
, EBioMedicine, ISSN: 2352-3964 -
Journal articleZhang-Zheng H, Adu-Bredu S, Duah-Gyamfi A, et al., 2024,
Contrasting carbon cycle along tropical forest aridity gradients in West Africa and Amazonia
, Nature Communications, ISSN: 2041-1723 -
Journal articleWang W, Gulliver J, Beevers S, et al., 2024,
Short-term nitrogen dioxide exposure and emergency hospital admissions for asthma in children: a case-crossover analysis in England
, Journal of Asthma and Allergy, ISSN: 1178-6965 -
Journal articleFlo V, Joshi J, Sabot M, et al., 2024,
Incorporating photosynthetic acclimation improves stomatal optimisation models
, Plant, Cell and Environment, ISSN: 0140-7791 -
Journal articleWood D, Evangelopoulos D, Beevers S, et al., 2024,
Exposure to ambient air pollution and cognitive function: an analysis of the English Longitudinal Study of Ageing cohort
, Environmental Health, ISSN: 1832-3367
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