Results
- Showing results for:
- Reset all filters
Search results
-
Journal articleGoodwin GM, Aaronson ST, Alvarez O, et al., 2026,
Corrigendum to "The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression" [Journal of Affective Disorders, Volume 372 (2025), Pages 523-532].
, J Affect Disord, Vol: 393 -
Journal articleIrrmischer M, Aqil M, Luan L, et al., 2026,
DMT-Induced Shifts in Criticality Correlate with Self-Dissolution.
, J Neurosci, Vol: 46Psychedelics profoundly alter subjective experience and brain dynamics. Brain oscillations express signatures of near-critical dynamics, relevant for healthy function. Alterations in the proximity to criticality have been suggested to underlie the experiential and neurological effects of psychedelics. Here, we investigate the effects of a psychedelic substance (DMT) on the criticality of brain oscillations, and in relation to subjective experience, in humans of either sex. We find that DMT shifts the dynamics of brain oscillations away from criticality in alpha and adjacent frequency bands. In this context, entropy is increased while complexity is reduced. We find that the criticality-shifts observed in alpha and theta bands correlate with the intensity ratings of self-dissolution, a hallmark of psychedelic experience. Finally, using a recently developed metric, the functional excitatory-inhibitory ratio, we find that the DMT-induced criticality-shift in brain oscillations is toward subcritical regimes. These findings have major implications for the neuronal understanding of the self and psychedelics, as well as for the neurological basis of altered states of consciousness.
-
Journal articleWall MB, Demetriou L, Giribaldi B, et al., 2026,
Thresholding and Perfusion Considerations in Interpreting Reduced Brain Responsiveness With Escitalopram: Response to Knudsen et al.
, Am J Psychiatry, Vol: 183, Pages: 80-81 -
Journal articleZafar R, 2025,
High hopes? Precision psychedelic addiction medicine
, Frontiers in Psychiatry, ISSN: 1664-0640Despite decades of neuroscience research and significant investment in addiction neuroimaging, clinical outcomes for individuals with substance use and behavioural addictions remain poor. Only 1.8% of people with substance use disorders receive effective treatment, highlighting a major disconnect between mechanistic understanding and clinical utility. This paper calls for a reorientation of addiction neuroscience, from a predominantly diagnostic focus toward a theragnostic framework, in which biomarkers are used to stratify patients, guide treatment decisions, and predict outcomes. We argue that the integration of translational neuroimaging biomarkers, particularly fMRI, EEG, and PET, within psychedelic addiction research offers a unique and timely opportunity to catalyse this shift. Psychedelic compounds such as psilocybin represent a new class of therapeutics capable of engaging neuroplasticity, reward and emotional processing, and cognitive control networks central to addiction pathophysiology. We review how acute and pre– post neuroimaging paradigms can index pharmacodynamic effects and longer-term treatment response and propose a roadmap for embedding biomarkers in early and late phase clinical trials. Drawing on ongoing studies at the Centre for Psychedelic Research at Imperial College London, we outline how multimodal biomarkers are being co-developed alongside clinical trials in gambling and opioid use disorders to identify biotype-specific responses and build a deeply phenotyped treatment population. We argue that these biomarkers, if validated, could serve as regulatory-grade tools for drug theragnostic co-development, mirroring successful models in oncology and 2 neurology. Importantly, we emphasise that realising this vision will require robust multi-stakeholder collaboration, including academia, industry, regulatory agencies, funders, healthcare systems, and patient groups alongside dedicated investment to build a scalable theragnostic infrastruct
-
Journal articleNutt DJ, 2025,
Farewell to Jim Watson (and Francis Crick). A reflection on their contributions to psychiatry and brain science.
, J Psychopharmacol -
Journal articleGordon AR, Carrithers BM, Pagni BA, et al., 2025,
The Effect of Psychedelics on Individuals with a Personality Disorder: Results from Two Prospective Cohort Studies
, PSYCHEDELIC MEDICINE, ISSN: 2831-4425 -
Journal articleMehmood MK, Bremler R, Spriggs MJ, et al., 2025,
Ceremonial Psychedelic Experiences and Changes in Mental Health Outcomes in Those with Adverse Childhood Experiences
, PSYCHEDELIC MEDICINE, ISSN: 2831-4425 -
Journal articleNutt DJ, 2025,
Obituary: Jan K. Melichar, BSc, MB, BS, MD, FRCPsych
, BJPSYCH BULLETIN, ISSN: 2056-4694 -
Journal articleHojlund M, Kafali HY, Kirmizi B, et al., 2025,
Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: A living systematic review with meta-analysis
, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 101, Pages: 41-55, ISSN: 0924-977X -
Journal articleBailey NW, Hill AT, Godfrey K, et al., 2025,
EEG is better when cleaning effectively targets artifacts
, CLINICAL NEUROPHYSIOLOGY, Vol: 180, ISSN: 1388-2457- Cite
- Citations: 1
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.
